1887

Abstract

Of 47 human sera tested, 13 converted serum-sensitive gonococci [strain BS4 (agar)] to serum resistance in vitro in 3 h at 37 C, as had previously been demonstrated for most samples of guinea pig serum. The resistance-inducing activity of human serum was lower than that of guinea pig serum but, like the latter, did not operate at 8 C, was greater at pH 6.6 than at pH 7.1, was increased by freezing and thawing, and depended on high and low molecular weight serum fractions; the latter fraction had a molecular weight between 1000 and 5000, and was acid- and heat-labile.

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/content/journal/micro/10.1099/00221287-127-1-213
1981-11-01
2024-04-23
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References

  1. Brooks G. F., Ingwer I., Petersen B. H. 1978; Importance of serum bactericidal and opsonic activity and complement in Neisseria gonorrhoeae infections. In Immunobiology of Neisseria gonorrhoeae pp. 199–203 Brooks G. F., Gotschlich E. C., Holmes K. K., Sawyer W. D., Young F. E. Edited by Washington, D.C.: American Society for Microbiology.;
    [Google Scholar]
  2. Goldner M., Penn C. W., Sanyal S. C., Veale D. R., Smith H. 1979; Phenotypically determined resistance of Neisseria gonorrhoeae to normal human serum: environmental factors in subcutaneous chambers in guinea pigs. Journal of General Microbiology 114:169–177
    [Google Scholar]
  3. McCutchan J. A., Levine S., Braude A. I. 1976; Influence of colony type on susceptibility of gonococci to killing by human serum. Journal of Immunology 116:1652–1655
    [Google Scholar]
  4. Penn C. W., Sen D., Veale D. R., Parsons N. J., Smith H., Witt K. 1976; Morphological, biological and antigenic properties of Neisseria gonorrhoeae adapted to growth in guinea pig subcutaneous chambers. Journal of General Microbiology 97:35–43
    [Google Scholar]
  5. Penn C. W., Veale D. R., Smith H. 1977; Selection from gonococci grown in vitro of a colony type with some virulence properties of organisms adapted in vivo. Journal of General Microbiology 100:147–158
    [Google Scholar]
  6. Rittenberg S. C., Penn C. W., Parsons N. J., Veale D. R., Smith H. 1977; Phenotypic changes in the resistance of Neisseria gonorrhoeae to killing by normal human serum. Journal of General Microbiology 103:69–75
    [Google Scholar]
  7. Schoolnik G. K., Buchanan T. M., Holmes K. K. 1976; Gonococci causing disseminated gonococcal infection are more resistant to the bactericidal action of normal human sera. Journal of Clinical Investigation 58:1163–1173
    [Google Scholar]
  8. Veale D. R., Smith H., Witt K. A., Marshall R. B. 1975; Differential ability of colonial types of Neisseria gonorrhoeae to produce infection and an inflammatory response in subcutaneous perforated plastic chambers in guinea pigs and rabbits. Journal of Medical Microbiology 8:325–335
    [Google Scholar]
  9. Veale D. R., Penn C. W., Parsons N. J., Smith H. 1980; Preliminary studies of a factor in guinea pig serum which induces serum resistance in Neisseria gonorrhoeae. Society for General Microbiology Quarterly 7:188
    [Google Scholar]
  10. Veale D. R., Penn C. W., Smith H. 1981; Factors affecting the induction of phenotypically determined serum resistance of Neisseria gonorrhoeae grown in media containing serum or its diffusible components. Journal of General Microbiology 122:235–245
    [Google Scholar]
  11. Ward M. E., Watt P. J., Glynn A. A. 1970; Gonococci in urethral exudates possess a virulence factor lost on subculture. Nature; London: 227382–384
    [Google Scholar]
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