1887

Abstract

Nitrofurantoin causes the stringent response in After exposure of a stringent strain to this drug, the intracellular concentrations of guanosine 3′-diphosphate 5′-diphosphate (ppGpp), guanosine 3′-diphosphate 5′-triphosphate (pppGpp) and ATP increased, while that of GTP decreased. In a relaxed strain no accumulation of ppGpp or pppGpp was observed, but both GTP and ATP declined after the addition of nitrofurantoin. Protein synthesis was equally sensitive to nitrofurantoin in both the stringent and relaxed strains, but the drug inhibited RNA accumulation only in the stringent strain, not in the relaxed strain. Nitrofurantoin also caused the accumulation of ppGpp in and

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-126-2-491
1981-10-01
2024-12-12
Loading full text...

Full text loading...

/deliver/fulltext/micro/126/2/mic-126-2-491.html?itemId=/content/journal/micro/10.1099/00221287-126-2-491&mimeType=html&fmt=ahah

References

  1. Anon 1976; New animal drug applications: furaltadone (NF 260), nitrofurazone (NF 73), nihydra-zone (NF 64) - opportunity for hearing on proposal to withdraw approval of certain new animal drug applications. Federal Register 4138884–34921
    [Google Scholar]
  2. Fortnagel P. 1981; Nitrofurans can partially overcome the glucose repression of sporulation. In Spores VIII Losick R. S., Tipper D., Sonenshein A. L. Edited by Washington, D.C.: American Society for Microbiology; (in the Press)
    [Google Scholar]
  3. Freese E., Heinze J. E., Galliers E. M. 1979; Partial purine deprivation causes sporulation of Bacillus subtilis in the presence of excess ammonia, glucose and phosphate. Journal of General Microbiology 115:193–205
    [Google Scholar]
  4. Gallant J. A. 1979; Stringent control in E. coli. Annual Review of Genetics 13:393–415
    [Google Scholar]
  5. Gallant J. A., Lazzarini R. 1976; The regulation of ribosomal RNA synthesis and degradation in bacteria. In Protein Synthesis: A Series of Advances pp. 309–359 McConkey E. Edited by New York: Dekker.;
    [Google Scholar]
  6. Grunberg E., Titsworth E. H. 1973; Chemotherapeutic properties of heterocyclic compounds: monocyclic compounds with five-membered rings. Annual Review of Microbiology 27:317–346
    [Google Scholar]
  7. Hamilton-Miller J. M. T., Brumfitt W. 1976; The versatility of nitro compounds. Antimicrobial Agents and Chemotherapy 2:5–7
    [Google Scholar]
  8. Haseltine W. A., Block R. 1973; Synthesis of guanosine tetra- and penta-phosphate requires the presence of a codon-specific uncharged transfer ribonucleic acid in the acceptor site of ribosomes. Proceedings of the National Academy of Sciences of the United States of America 70:1564–1568
    [Google Scholar]
  9. Heinze J. E., Mitani T., Rich K. E., Freese E. 1978; Induction of sporulation by inhibitory purines and related compounds. Biochimica et biophysica acta 521:16–26
    [Google Scholar]
  10. Herrlich P., Schweiger M. 1976; Nitrofurans, a group of synthetic antibiotics with a new mode of action: discrimination of specific messenger RNA classes. Proceedings of the National Academy of Sciences of the United States of America 73:3386–3390
    [Google Scholar]
  11. Lopez J. M., Marks C., Freese E. 1979; The decrease of guanine nucleotides initiates sporulation of Bacillus subtilis. Biochimica et biophysica acta 587:238–252
    [Google Scholar]
  12. Lopez J. M., Ochi K., Freese E. 1981; Initiation of Bacillus subtilis sporulation caused by the stringent response. In Spores VIII. Losick R. S., Tipper D., Sonenshein A. L. Edited by Washington, D.C.: American Society for Microbiology; (in the Press)
    [Google Scholar]
  13. McCalla D. R. 1979; Nitrofurans. In Antibiotics V, Part 1: Mechanism of Action of Antibacterial Agents pp. 176–213 Haun F. E. Edited by New York: Springer.;
    [Google Scholar]
  14. Mitani T., Heinze J. E., Freese E. 1977; Induction of sporulation in Bacillus subtilis by decoyinine and hadacidine. Biochemical and Biophysical Research Communications 77:1118–1125
    [Google Scholar]
  15. Sands M. K., Roberts R. B. 1952; The effects of a tryptophan-histidine deficiency in a mutant of Escherichia coli. Journal of Bacteriology 63:505–511
    [Google Scholar]
  16. Tu Y., McCalla D. R. 1976; Effect of nitrofurazone on bacterial RNA and ribosome synthesis and on the function of ribosomes. Chemico-Biological Interactions 14:81–91
    [Google Scholar]
/content/journal/micro/10.1099/00221287-126-2-491
Loading
/content/journal/micro/10.1099/00221287-126-2-491
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error