1887

Abstract

Fungicides inhibiting sterol biosynthesis belong to chemically distinct classes such as imidazole, morpholine, pyridine, pyrimidine and triazole derivatives. Incubation of mycelium of for 90 min with representatives of these fungicides induced an efflux activity which prevented accumulation of fenarimol, a pyrimidine derivative, into the mycelium. Induction of this efflux activity reduced the fungitoxicity of fenarimol. Addition of oligomycin to mycelium in which fenarimol-efflux activity was induced immediately increased the uptake of fenarimol, indicating that the efflux activity is energy-dependent. Subsequent disruption of membrane permeability with sodium lauryl sulphate instantaneously caused leakage of fenarimol from the mycelium into the medium. The ability to induce fenarimol efflux is rather specific for inhibitors of sterol biosynthesis: except for pimaricin, fungicides with unrelated mechanisms of action did not have this ability.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-126-2-483
1981-10-01
2020-01-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-126-2-483
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error