1887

Abstract

Electron microscopic observations of acutely infected rabbit testes showed that the majority of were extracellular, and confined to interstitial regions of the tissue. Organisms were often adjacent to small blood vessels, where they should be freely accessible to non-specific humoral and cellular defence mechanisms. However, there was no accumulation of leucocytes in blood vessels or infiltration of inflammatory cells into infected areas. Inoculation of live treponemes into perforated plastic chambers which had been implanted subcutaneously in rabbits or guinea-pigs did not incite significant infiltration into the chamber fluid of inflammatory cells, in contrast to that seen after inoculation of Interaction of antibody from infected rabbits with live treponemes freshly extracted from rabbit testes could not be detected by an indirect fluorescent antibody method. These observations suggest that escapes recognition by host defences.

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1981-09-01
2021-05-18
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References

  1. Alderete J. F., Baseman J. B. 1979; Surface-associated host proteins on virulent Treponema pallidum. . Infection and Immunity 26:1048–1056
    [Google Scholar]
  2. Azar H. A., Pham T. D., Kurban A. K. 1970; An electron microscopic study of a syphilitic chancre. Archives of Pathology 90:143–150
    [Google Scholar]
  3. Baseman J. B., Nichols J. C., Hayes N. S. 1976; Virulent Treponema pallidum: aerobe or anaerobe? . Infection and Immunity 13:704–711
    [Google Scholar]
  4. Brause B. D., Roberts R. B. 1978; Attachment of virulent Treponema pallidum to human mononuclear phagocytes. British Journal of Venereal Diseases 54:218–224
    [Google Scholar]
  5. Christiansen S. 1963; Protective layer covering pathogenic Treponemata. Lancet 1:423–425
    [Google Scholar]
  6. Cox C. D., Barber M. K. 1974; Oxygen uptake by Treponema pallidum. . Infection and Immunity 10:123–127
    [Google Scholar]
  7. Drusin L. M., Rouiller G. C., Chapman G. B. 1969; Electron microscopy of Treponema pallidum occurring in a human primary lesion. Journal of Bacteriology 97:951–955
    [Google Scholar]
  8. Fitzgerald T. J., Johnson R. C., Sykes J. A., Miller J. N. 1977; Interaction of Treponema pallidum (Nichols strain) with cultured mammalian cells: effects of oxygen, reducing agents, serum supplements and different cell types. Infection and Immunity 15:444–452
    [Google Scholar]
  9. Hasegawa T. 1969; Electron microscopic observations on the lesions of condyloma latum. British Journal of Dermatology 81:367–374
    [Google Scholar]
  10. Hayes N. J., Muse K. E., Collier A. M., Baseman J. B. 1977; Parasitism by virulent Treponema pallidum of host cell surfaces. Infection and Immunity 17:174–186
    [Google Scholar]
  11. Holt S. C. 1978; Anatomy and chemistry of spirochaetes. Microbiological Reviews 42:114–160
    [Google Scholar]
  12. Jepsen O. B., Hovind-Hougen K., Birch-Andersen A. 1968; Electron microscopy of Treponema pallidum Nichols. Acta pathologica et microbiologica scandinavica 74:241–258
    [Google Scholar]
  13. Johnson R. C., Ritzi D., Livermore B. 1973; Outer envelope of virulent Treponema pallidum. . Infection and Immunity 8:291–295
    [Google Scholar]
  14. Lauderdale V., Goldman J. N. 1972; Serial ultrathin sectioning demonstrating the intracellularity of Treponema pallidum. . British Journal of Venereal Diseases 48:87–96
    [Google Scholar]
  15. Lukehart S. A., Baker-Zander S. A., Lloyd R. M. C., Sell S. 1980; Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesions. Journal of Immunology 124:461–467
    [Google Scholar]
  16. Musher D. M., Baughn R. E., Knox J. M. 1979; Infection due to Treponema pallidum-escape from immune surveillance. In Immune Mechanisms and Disease pp. 341–352 Amos D. B., Schwartz R. S., Janicki. B. W. Edited by New York: Academic Press.;
    [Google Scholar]
  17. Nelson R. A., Diesendruck J. A. 1951; Studies on treponemal immobilising antibodies in syphilis. Journal of Immunology 66:667–685
    [Google Scholar]
  18. Norris S. J., Miller J. N., Sykes J. A., Fitzgerald T. J. 1978; Influence of oxygen tension, sulfhydryl compounds and serum on the motility and virulence of Treponema pallidum(Nichols strain) in a cell free system. Infection and Immunity 22:689–697
    [Google Scholar]
  19. Report 1980; Sexually transmitted diseases. Extract from the Annual Report of the Chief Medical Officer of the Department of Health and Social Security for the Year 1978. British Journal of Venereal Diseases 56:178–181
    [Google Scholar]
  20. Sykes J. A., Miller J. N. 1971; Intracellular location of Treponema pallidum (Nichols strain) in the rabbit testis. Infection and Immunity 4:307–314
    [Google Scholar]
  21. Sykes J. A., Miller J. N. 1973; Ultrastructural studies of treponemes: location of axial filaments and some dimensions of Treponema pallidum (Nichols strain).Treponema denticola, and Treponema reiteri. . Infection and Immunity 7:100–110
    [Google Scholar]
  22. Sykes J. A., Miller J. N., Kalan A. J. 1974; Treponema pallidum within cells of a primary chancre from a human female. British Journal of Venereal Diseases 50:40–44
    [Google Scholar]
  23. Taussig M. J. 1979 Processes in Pathology. Oxford: Blackwell Scientific Publications.;
    [Google Scholar]
  24. Turk J. L. 1979; Immunology of chronic infections. In Immunological A spects of Infectious Disease pp. 421–460 Dick. G. Edited by Lancaster: MTP Press.;
    [Google Scholar]
  25. Turner T. B., Hollander D. H. 1957; Biology of the treponematoses. W.H.O. Monograph Series No. 37. Geneva: W.H.O.;
    [Google Scholar]
  26. Veale D. R., Smith H., Witt. K.A, Marshall R. B. 1975; Differential ability of colonial types of Neisseria gonorrhoeae to produce infection and an inflammatory response in subcutaneous perforated plastic chambers in guinea-pigs and rabbits. Journal of Medical Microbiology 8:325–335
    [Google Scholar]
  27. Walter J. B., Israel M. S. 1979 General Pathology, 5th. Edinburgh: Churchill Livingstone.;
    [Google Scholar]
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