1887

Abstract

Several chlorate-resistant mutants of were isolated and analysed; all were affected in nitrate assimilation. Nine loci were recognized by complementation analysis and these appear to be equivalent to the (nitrate reductase structural gene), (control locus) and seven loci (responsible for the biosynthesis of a cofactor for nitrate reductase) of . The organization of the nitrate assimilation genes appears to be similar in both organisms, even to the extent of having contiguous genes coding for the nitrate and nitrite reductase enzymes.

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1981-04-01
2021-10-19
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References

  1. Armitt S., Mccullough W., Roberts C.F. 1976; Analysis of acetate non-utilizing (acu) mutants in Aspergillus nidulans . Journal of General Microbiology 92:263–282
    [Google Scholar]
  2. Arst H.N. Jr Macdonald D.W., Cove D.J. 1970; Molybdate metabolism in Aspergillus nidulans. I. Mutations affecting nitrate reductase and/or xanthine dehydrogenase. Molecular and General Genetics 108:129–145
    [Google Scholar]
  3. Ball C. 1971; Haploidization analysis in Penicillium chrysogenum . Journal of General Microbiology 66:63–69
    [Google Scholar]
  4. Cove D.J. 1970; Control of gene action in Aspergillus nidulans . Proceedings of the Royal Society B176:267–275
    [Google Scholar]
  5. Cove D.J. 1976a; Chlorate toxicity in Aspergillus nidulans: the selection and characterisation of chlorate resistant mutants. Heredity 36:191–203
    [Google Scholar]
  6. Cove D.J. 1976b; Chlorate toxicity in Aspergillus nidulans: studies of mutants altered in nitrate assimilation. Molecular and General Genetics 146:147–159
    [Google Scholar]
  7. Cove D.J., Pateman J.A. 1963; Independently segregating loci concerned with nitrate reductase activity in Aspergillus nidulans . Nature; London: 198262–263
    [Google Scholar]
  8. Ditchburn P., Holt G., Macdonald K.D. 1976; The genetic location of mutations increasing penicillin yield in Aspergillusnidulans . In Second International Symposium on the Genetics of Industrial Microorganisms pp. 213–227 Macdonald K.D. Edited by London:: Academic Press.;
    [Google Scholar]
  9. Edwards G.F.STL., Holt G., Macdonald K.D. 1974; Mutants of Aspergillus nidulans impaired in penicillin biosynthesis. Journal of General Microbiology 84:420–422
    [Google Scholar]
  10. Holt G., Macdonald K.D. 1968a; Penicillin production and its mode of inheritance in Aspergillus nidulans . Antonie van Leeuwenhoek 34:409–416
    [Google Scholar]
  11. Holt G., Macdonald K.D. 1968b; Isolation of strains with increased penicillin yield after hybridisation in Aspergillus nidulans . Nature; London: 219636–637
    [Google Scholar]
  12. Huskey R.J., Semenkovich C.F., Griffin B.E., Cecil P.O., Callahan A.M., Chace K.V., Kirk D.L. 1979; Mutants of Volvox carteri affecting nitrogen assimilation. Molecular and General Genetics 169:157–161
    [Google Scholar]
  13. Lewis C.M., Fincham J.R.S. 1970; Genetics of nitrate reductase in Ustilago maydis . Genetical Research 16:151–163
    [Google Scholar]
  14. Macdonald K.D., Hutchinson J.M., Gillet W.A. 1963a; Isolation of auxotrophs of Penicillium chrysogenum and their penicillin yields. Journal of General Microbiology 33:365–374
    [Google Scholar]
  15. Macdonald K.D., Hutchinson J.M., Gillet W.A. 1963b; Heterokaryon studies and the genetic control of penicillin and chrysogenin production in Penicillium chrysogenum . Journal of General Microbiology 33:375–383
    [Google Scholar]
  16. Macdonald K.D., Hutchinson J.M., Gillet W.A. 1963c; Formation and segregation of heterozygous diploids between wild-type strain and derivatives of high penicillin yield in Penicillium chrysogenum . Journal of General Microbiology 33:385–394
    [Google Scholar]
  17. Merrick M.J. 1975a; Hybridization and selection for increased penicillin titre in wild-type isolates of Aspergillus nidulans . Journal of General Microbiology 91:278–286
    [Google Scholar]
  18. Merrick M.J. 1975b; The inheritance of penicillin titre in crosses between lines of Aspergillus nidulans selected for increased productivity. Journal of General Microbiology 91:287–294
    [Google Scholar]
  19. Merrick M.J., Caten C.E. 1975a; The design of fermentation and biological assay procedures for assessment of penicillin production in populations of Aspergillus nidulans . Journal of Applied Bacteriology 38:121–131
    [Google Scholar]
  20. Merrick M.J., Caten C.E. 1975b; The inheritance of penicillin titre in wild-type isolates of Aspergillus nidulans . Journal of General Microbiology 86:283–293
    [Google Scholar]
  21. Nichols G.L., Syrett P.J. 1978; Nitrate reductase deficient mutants of Chlamydomonas reinhardii. Isolation and genetics. Journal of General Microbiology 108:71–77
    [Google Scholar]
  22. Pateman J.A., Cove D.J. 1967; Regulation of nitrate reduction in Aspergillus nidulans . Nature; London: 2151234–1237
    [Google Scholar]
  23. Pateman J.A., Cove D.J., Rever B.M., Roberts D.B. 1964; A common cofactor for nitrate reductase and xanthine dehydrogenase which also regulates the synthesis of nitrate reductase. Nature; London: 20158–60
    [Google Scholar]
  24. Pateman J.A., Rever B.M., Cove D.J. 1967; Genetics and biochemical studies of nitrate reduction in Aspergillus nidulans . Biochemical Journal 104:103–111
    [Google Scholar]
  25. Pléchaud M., Puig J., Plchinoty F., Azoulay E., Le Minor L. 1967; Mutation affectant la nitrate-réductase A et d’autre enzymes bactériennes d’oxydo-réduction. Etude preliminaire. Annales de l’Institut Pasteur 112:24–37
    [Google Scholar]
  26. Rand K.N. 1978 Aspects of the control of nitrogen metabolism in Aspergillus nidulans. Ph.D. thesis University of Cambridge.:
    [Google Scholar]
  27. Rand K.N., Arst H.N. Jr 1977; A mutation in Aspergillus nidulans which affects the regulation of nitrite reductase and is tightly linked to its structural gene. Molecular and General Genetics 155:67–75
    [Google Scholar]
  28. Rever B.M. 1965 Biochemical and genetical studies of inorganic nitrogen metabolism in Aspergillus nidulans. Ph.D. thesis University of Cambridge.:
    [Google Scholar]
  29. Roberts C.F. 1959; A replica plating technique for the isolation of nutritionally exacting mutants of a filamentous fungus (Aspergillusnidulans) . Journal of General Microbiology 20:540–548
    [Google Scholar]
  30. Scazzocchio C. 1974; The genetic determination of molybdoflavoenzymes in Aspergillus nidulans . Journal of Less-Common Metals 36:461–464
    [Google Scholar]
  31. Simpson I.N., Caten C.E. 1979; Induced quantitative variation for penicillin titre in clonal populations of Aspergillus nidulans . Journal of General Microbiology 110:1–12
    [Google Scholar]
  32. Stauffer J.F., Backus M.P. 1954; Spontaneous and induced variation in selected stocks of the Penicilliumchrysogenum series. Annals of the New York Academy of Sciences 60: art. 1.
    [Google Scholar]
  33. Stouthamer A.H. 1967; Nitrate reduction in Aerobacter aerogenes. I. Isolation and properties of mutant strains blocked in nitrate assimilation and resistant against chlorate. Archiv für Mikrobiologie 56:68–75
    [Google Scholar]
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