1887

Abstract

The germination of blastospores of is accompanied by a rise in the intracellular concentration of adenosine 3′:5′-cyclic monophosphate (cyclic AMP). Germination was induced either by peptides isolated from seminal plasma or by an amino acid mixture, and both germination and the rise in cyclic AMP required a temperature of 37 °C. The rise occurred during the first hour of incubation, but full germination required a temperature of 37 °C for 4 h. Germination and the rise in cyclic AMP, in the presence of suboptimal concentrations of inducers, were stimulated by theophylline. Pre-incubation of cells with dithiothreitol in the absence of inducers inhibited subsequent germination but not the rise in cyclic AMP. Germination and the rise in cyclic AMP were inhibited if dithiothreitol or -succinimidyl-3-(4-hydroxyphenyl)propionate was present during the induction period.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-123-2-233
1981-04-01
2021-05-06
Loading full text...

Full text loading...

/deliver/fulltext/micro/123/2/mic-123-2-233.html?itemId=/content/journal/micro/10.1099/00221287-123-2-233&mimeType=html&fmt=ahah

References

  1. Barlow A.J.E., Aldersley T., Chattaway F.W. 1974; Factors present in serum and seminal plasma which promote germ-tube formation and mycelial growth of Candida albicans . Journal of General Microbiology 82:261–272
    [Google Scholar]
  2. Bolton A.E., Hunter W.M. 1973; The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Biochemical Journal 133:529–539
    [Google Scholar]
  3. Braun P.C., Calderone R.A. 1978; Chitin synthesis in Candida albicans: comparison of yeast and hyphal forms. Journal of Bacteriology 133:1472–1477
    [Google Scholar]
  4. Chattaway F.W., Holmes M.R., Barlow A.J.E. 1968; Cell wall composition of the mycelial and blastospore forms of Candida albicans . Journal of General Microbiology 51:367–376
    [Google Scholar]
  5. Chattaway F.W., Bishop R., Holmes M.R., Odds F.C., Barlow A.J.E. 1973; Enzyme activities associated with carbohydrate synthesis and breakdown in the yeast and mycelial forms of Candida albicans . Journal of General Microbiology 75:97–109
    [Google Scholar]
  6. Chattaway F.W., O’Reilly J., Barlow A.J.E., Aldersley T. 1976; Induction of the mycelial form of Candida albicans by hydrolysates of peptides from seminal plasma. Journal of General Microbiology 96:317–322
    [Google Scholar]
  7. Chattaway F.W., O’Reilly J., Wheeler P., Barlow A.J.E. 1979 Abstracts of VHth Congress of the International Society for Human and Animal Mycology, Israel p. 7:
    [Google Scholar]
  8. Chattaway F.W., Wheeler P.R., O’Reilly J. 1980; Purification and properties of peptides which induce germination of blastospores of Candida albicans . Journal of General Microbiology 120:431–437
    [Google Scholar]
  9. Evans E.G.V., Odds F.C., Holland K.T. 1975; Resistance of the Candida albicans filamentous cycle to environmental change. Sabouraudia 13:231–238
    [Google Scholar]
  10. Gilman A.G., Mourad F. 1974; Assay of cyclic nucleotides by receptor protein binding displacement. Methods in Enzymoiogy 38:49–57
    [Google Scholar]
  11. Gunasekaran M., Hughes W.T., Maguire W.J. 1976; Cyclic 3ʹ,5ʹ-nucleotide phosphodiesterase of Candida albicans . Microbios Letters 3:47–53
    [Google Scholar]
  12. Hamberg M., Samuelsson B. 1966; Prostaglandins in human seminal plasma. Prostaglandins and related factors 46. Journal of Biological Chemistry 241:257–263
    [Google Scholar]
  13. Land G.A., Mcdonald W.C., Stjernholm R.L., Friedman L. 1975a; Factors affecting filamentation in Candida albicans. Relationship of the uptake and distribution of proline to morphogenesis. Infection and Immunity 11:1014–1023
    [Google Scholar]
  14. Land G.A., Mcdonald W.C., Stjernholm R.L., Friedman L. 1975b; Factors affecting filamentation in Candida albicans. Changes in respiratory activity of Candida albicans during filamentation. Infection and Immunity 12:119–127
    [Google Scholar]
  15. Larsen A., Sypherd P.S. 1974; Cyclic adenosine 3ʹ,5ʹ-monophosphate and morphogenesis in Mucor racemosus . Journal of Bacteriology 117:432–438
    [Google Scholar]
  16. Maresca B., Medoff G., Schlessinger D., Kobayashi G.S. 1977; Regulation of dimorphism in the pathogenic fungus Histoplasma capsulatum . Nature; London: 266447–448
    [Google Scholar]
  17. Mattia E., Cassone A. 1979; Inducibility of germ-tube formation in Candida albicans at different phases of yeast growth. Journal of General Microbiology 113:439–442
    [Google Scholar]
  18. Nickerson W.J., Falcone G. 1956; Identification of protein disulphide reductase as a cellular division enzyme in yeasts. Science 124:722
    [Google Scholar]
  19. Niimi M., Niimi K., Tokunaga J., Nakayama H. 1980; Changes in cyclic nucleotide levels and dimorphic transitions in Candida albicans . Journal of Bacteriology 142:1010–1014
    [Google Scholar]
  20. Paznokas J.L., Sypherd P.S. 1975; Respiratory capacity, cyclic adenosine 3ʹ,5ʹ-monophosphate and morphogenesis of Mucor racemosus . Journal of Bacteriology 124:134–139
    [Google Scholar]
  21. Samuelsson B., Goldyne M., Granstrom E., Hamberg M., Hammerström S., Malmsten C. 1978; Prostaglandins and thromboxanes. Annual Review of Biochemistry 47:997–1029
    [Google Scholar]
  22. Soll D.R., Bedell G.W. 1978; Bud formation and the inducibility of pseudo-mycelium outgrowth during release from stationary phase in Candida albicans . Journal of General Microbiology 108:173–180
    [Google Scholar]
  23. Walton G.M. 1970; An assay for adenosine 3ʹ-5ʹ-cyclic monophosphate based on the association of the nucleotide with partially purified binding protein. Biochemistry 9:4223–4229
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-123-2-233
Loading
/content/journal/micro/10.1099/00221287-123-2-233
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error