SUMMARY: Glutamic acid was excreted by strain C3. which carries the extrachromosomal S factor, but not by strains lacking S factor. There was a correlation between the isocitrate dehydrogenase activity of cell-free extracts and the rate of glutamate excretion by various strains. Differences were detected in the K for isocitrate, the specific activity and stability of isocitrate dehydrogenase from strains CBC356 and C3 which differ in their ability to excrete glutamate. We suggest that the S factor plasmid is required for isocitrate dehydrogenase synthesis in C3 and that this enzyme plays an important role in the regulation of glutamate excretion.


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