SUMMARY: The changes in bacterial density, total extracellular protein and haemolysin produced by bacteria from overnight cultures of (Wood 46) and a low α-toxin-producing variant suspended in fresh medium were followed at 37°C. Although five extracellular proteins were produced at a reduced level by the variant (α-toxin formation was reduced more than tenfold), the differential rates of total extracellular protein formation by the two organisms were identical. The results are consistent with a common regulatory mechanism for extracellular protein formation in which a pleiotropic compensation may occur in order to saturate the extracellular protein-producing capability.


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