@article{mbs:/content/journal/micro/10.1099/00221287-121-2-473, author = "Salcher, Olga and Lingens, Franz", title = "Regulation of Phospho-2-keto-3-deoxy-heptonate Aldolase (DAHP Synthase) and Anthranilate Synthase of Pseudomonas aureofaciens", journal= "Microbiology", year = "1980", volume = "121", number = "2", pages = "473-476", doi = "https://doi.org/10.1099/00221287-121-2-473", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-121-2-473", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "Phospho-2-keto-3-deoxy-heptonate aldolase (DAHP synthase) of Pseudomonas aureofaciens ATCC 15926 was inhibited by l-tyrosine. The inhibition was competitive with erythrose 4-phosphate as the varied substrate but non-competitive with respect to phosphoenol-pyruvate. Anthranilate synthase was inhibited by L-tryptophan. The inhibition was competitive with respect to chorismate but non-competitive with l-glutamine or NH4 +as the varied substrate. DAHP synthase and anthranilate synthase were not repressed when aromatic amino acids were included in the growth medium. In bacteria grown in the presence of l-phenylalanine, the anthranilate synthase activity was enhanced about threefold compared with the control. Similar results were obtained with the mutant strain P. aureofaciens ACN, which produces increased amounts of pyrrolnitrin.", }