RT Journal Article SR Electronic(1) A1 Benson Charles, E. A1 Hornick David, L. A1 Gots Joseph, S.YR 1980 T1 Genetic Separation of Purine Transport from Phosphoribosyltransferase Activity in Salmonella typhimurium JF Microbiology, VO 121 IS 2 SP 357 OP 364 DO https://doi.org/10.1099/00221287-121-2-357 PB Microbiology Society, SN 1465-2080, AB Two mutants of Salmonella typhimurium were isolated which differ from their respective parental strains in their growth responses to guanine and xanthine. Both mutants had purine phosphoribosyltransferase activities similar to their parental strains. One mutant, CB-3, had a lower guanine uptake rate apparently caused by a genetic lesion in a specific gene (designated guaP) responsible for facilitating the transport of guanine. This gene mapped at 3ยท5 min in the sequence azi-guaP-nadC. The second mutant, GP103, had a purine carrier molecule with altered specificity, as demonstrated by a competition between hypoxanthine and xanthine for uptake., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-121-2-357