@article{mbs:/content/journal/micro/10.1099/00221287-121-2-357, author = "Benson Charles, E. and Hornick David, L. and Gots Joseph, S.", title = "Genetic Separation of Purine Transport from Phosphoribosyltransferase Activity in Salmonella typhimurium", journal= "Microbiology", year = "1980", volume = "121", number = "2", pages = "357-364", doi = "https://doi.org/10.1099/00221287-121-2-357", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-121-2-357", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "Two mutants of Salmonella typhimurium were isolated which differ from their respective parental strains in their growth responses to guanine and xanthine. Both mutants had purine phosphoribosyltransferase activities similar to their parental strains. One mutant, CB-3, had a lower guanine uptake rate apparently caused by a genetic lesion in a specific gene (designated guaP) responsible for facilitating the transport of guanine. This gene mapped at 3ยท5 min in the sequence azi-guaP-nadC. The second mutant, GP103, had a purine carrier molecule with altered specificity, as demonstrated by a competition between hypoxanthine and xanthine for uptake.", }