1887

Abstract

Viomycin and capreomycin, antibiotics produced by and respectively, are potent inhibitors of bacterial protein synthesis. Although these organisms are highly tolerant of their own products , their ribosomes are fully sensitive to the action of the drugs However, they possess novel, antibiotic-inactivating enzymes (viomycin phosphotransferase, capreomycin phosphotransferase, capreomycin acetyl-transferase) which, in addition to possible biosynthetic roles, may contribute to the resistances observed

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1980-09-01
2024-12-03
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References

  1. Algeorge G., Petre A. 1970; Some experimental aspects of cross-resistance between capreomycin and viomycin. Antibiotica et chemo- therapia 16:32–35
    [Google Scholar]
  2. Benveniste R., Davies J. 1973; Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proceedings of the National Academy of Sciences of the United States of America 70:2276–2280
    [Google Scholar]
  3. Caltrider P. G. 1967; Viomycin. In Antibiotics I pp. 677–680 Edited by Gottlieb D., Shaw P. D. Berlin: Springer-Verlag;
    [Google Scholar]
  4. Cella R., Vining L. C. 1974; Action of streptomycin on growth of Streptomyces griseus. Canadian Journal of Microbiology 20:1591–1597
    [Google Scholar]
  5. Cundliffe E. 1978; Mechanism of resistance to thiostrepton in the producing organism, Streptomyces azureus. Nature, London 272:792–795
    [Google Scholar]
  6. Cundliffe E., Thompson J. 1979; Ribose methylation and resistance to thiostrepton. Nature, London 278:859–861
    [Google Scholar]
  7. Cundliffe E., Dixon P., Stark M., Stöffler G., Ehrlich R., Stöffler-Meilicke M., Cannon M. 1979; Ribosomes in thiostrepton-resistant mutants of Bacillus megaterium lacking a single 50S subunit protein. Journal of Molecular Biology 132:235–252
    [Google Scholar]
  8. Davies J., Smith D. I. 1978; Plasmid-determined resistance to antimicrobial agents. Annual Review of Microbiology 32:469–518
    [Google Scholar]
  9. Dyer J. R., Kellogg C. K., Nassar R. F., Streetman W. E. 1965; The structure of viomycin. Tetrahedron Letters585–592
    [Google Scholar]
  10. Herr E. B. 1963; Chemical and biological properties of capreomycin and other peptide antibiotics. In Antimicrobial Agents and Chemotherapy - 1962 pp. 201–212 Edited by Sylvester J. C. Michigan: American Society for Microbiology.;
    [Google Scholar]
  11. Herr E. B., Redstone M. O. 1966; Chemical and physical characterization of capreomycin. Annals of the New York Academy of Sciences 135:940–946
    [Google Scholar]
  12. Herr E. B., Haney M. E., Pittenger G. F., Higgens C. E. 1960; Isolation and characterization of a new peptide antibiotic. Proceedings of the Indiana Academy of Sciences 69:134
    [Google Scholar]
  13. Jones D. A., Rodnight R. 1971; Protein-bound phosphoserine in acid hydrolyzates of brain tissue. Biochemical Journal 121:597–600
    [Google Scholar]
  14. Liou Y.-F., Tanaka N. 1976; Dual actions of viomycin on the ribosomal functions. Biochemical and Biophysical Research Communications 71:477–483
    [Google Scholar]
  15. Mcclatchy J. K., Kanes W., Davidson P. T., Moulding T. S. 1977; Cross-resistance in M. tuberculosis to kanamycin, capreomycin and viomycin. Tubercle 58:29–34
    [Google Scholar]
  16. Malik V. S., Vining L. C. 1972; Chlorampheni col resistance in a chloramphenicol-producing Streptomyces. Canadian Journal of Microbiology 18:583–590
    [Google Scholar]
  17. Misumi M., Tanaka N. 1978; Binding of [14C]- tuberactinomycin O, an antibiotic closely related to viomycin, to the bacterial ribosome. Biochemical and Biophysical Research Communications 82:971–976
    [Google Scholar]
  18. Modolell J., Vazquez D. 1977; The inhibition of ribosomal translocation by viomycin. European Journal of Biochemistry 81:491–497
    [Google Scholar]
  19. Nomoto S., Teshima T., Wakamiya T., Shiba T. 1977; The revised structure of capreomycin. Journal of Antibiotics 30:955–959
    [Google Scholar]
  20. Okami L., Hashimoto T., Suzuki M. 1969; Sensitivity of actinomycetes to antibiotics as a guide to identification. Journal of Antibiotics 13:223–227
    [Google Scholar]
  21. Ozanne B., Benveniste R., Tipper D., Davies J. 1969; Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors. Journal of Bacteriology 100:1144–1146
    [Google Scholar]
  22. Pass L., Raczynska-Bojanowska K. 1968; On the inhibition mechanisms of viomycin synthesis by inorganic phosphate. Acta biochimica polonica 15:355–367
    [Google Scholar]
  23. Piwowarski J. M., Shaw P. D. 1979; Streptomycin-resistance in a streptomycin-producing organism. Antimicrobial Agents and Chemotherapy 16:176–182
    [Google Scholar]
  24. Reid T. W., Wilson I. B. 1971; E. coli alkaline phosphatase. In The Enzymes IV, 3rd edn. pp. 373–415 Edited by Boyer P. D. New York: Academic Press.;
    [Google Scholar]
  25. Teraoka H., Tanaka K. 1974; Properties of ribosomes from Streptomyces erythreus and Streptomyces griseus. Journal of Bacteriology 120:316–321
    [Google Scholar]
  26. Tsukamura M. 1969; Cross-resistance relationships between capreomycin, kanamycin and viomycin resistances in tubercle bacilli from patients. American Review of Respiratory Disease 99:780–782
    [Google Scholar]
  27. Walker M. S., Walker J. B. 1970; Streptomycin biosynthesis and metabolism. Journal of Biological Chemistry 245:6683–6689
    [Google Scholar]
  28. Yamada T., Mizuguchi Y., Nierhaus K. H., Wittmann H. G. 1978; Resistance to viomycin conferred by RNA of either ribosomal subunit. Nature, London 275:460–461
    [Google Scholar]
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