The Differences in Antibiotic Sensitivity of Closely Related Single Cells of Proteus vulgaris

W. Howard Hughes

doi:10.1099/00221287-12-2-269

Volume 12, Issue 2

Research Article

Free

The Differences in Antibiotic Sensitivity of Closely Related Single Cells of Proteus vulgaris

W. Howard Hughes¹
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Affiliations: ¹ Wright-Fleming Institute of Microbiology, St Mary’s Hospital Medical School, London, W. 2
Published: 01 April 1955 https://doi.org/10.1099/00221287-12-2-269

Abstract

SUMMARY:Evidence is offered that when a single bacterial cell divides the daughter cells are frequently unlike one another. This can be demonstrated by separating cells, allowing them to divide and then transferring individuals derived from them to agar containing a suitable concentration of antibiotic. Differences between single cells can be tested by four criteria: (1) division; (2) growth without division: (3) ability to resume division when transferred back to normal broth; (4) failure to lyse.

Published Online: 01/04/1955

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References

Eagle H., Fleischmann R., Levy M. 1952; Development of increased bacterial resistance to antibiotics. J. Bact. 63:623
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Rowley D. 1952; Selection of penicillin-sensitive mutants ofEscherichia coli following ultra-violet irradiation. J. gen. Microbiol. 6:272
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The Differences in Antibiotic Sensitivity of Closely Related Single Cells of Proteus vulgaris

Microbiology 12, 269 (1955); https://doi.org/10.1099/00221287-12-2-269

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Volume 12, Issue 2

Research Article

Free

The Differences in Antibiotic Sensitivity of Closely Related Single Cells of Proteus vulgaris

Abstract

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