SUMMARY: The bactericidal activity of streptomycin, isoniazid and combinations of streptomycin and isoniazid against tubercle bacilli growing in Tween albumin medium was measured with and without the addition of -aminosalicylic acid (PAS). When the concentrations of these compounds were about 4 to 16 times their minimal inhibitory concentrations, PAS did not influence this activity, but it was slightly increased when the concentrations were 10 times higher (equal to peak serum concentrations in treated patients). Combinations of the low concentrations of PAS + streptomycin or PAS + isoniazid usually only delayed the emergence of drug-resistant bacilli, whereas combinations of the higher concentrations suppressed their growth.


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