We have previously described a large family of mutants of which were selected by continuous culture on xylitol and which superproduce ribitol dehydrogenase. One of these strains was found to harbour a high copy number 2.1 × 10 dalton plasmid. This plasmid is a deletion derivative of a low copy number 3.5 × 10 dalton plasmid present in the ancestral strain of . However, since these plasmids do not contain the genes required for pentitol catabolism and some enzyme-superproducing strains have lost all DNA homologous to the plasmids, they are not implicated in the fast growth on xylitol. The plasmids contain regions of homology with the plasmid ColE1.


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