Summary: Two nystatin-resistant mutants of were isolated and identified as and Analysis of the sterol composition of these cells indicated a total absence of ergosterol and an increased level of a possible precursor. Successive cultures of the resistant strains in a medium supplemented with 10 μ ergosterol ml induced in 5 d a sensitivity to nystatin identical to that of the wild-type strain. These ergosterol-supplemented strains had an ergosterol content similar to that of the wild-type strain cultured in the absence of ergosterol. Resistance to nystatin was recovered after 5 d subculture in medium without ergosterol.


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