Summary: The genetic basis for spontaneous resistance to tetracyline (Tet) and penicillin (Pen) in was investigated. and are polygenes which confer small but distinct levels of resistance to Tet and Pen, respectively. is a multiple-drug resistance polygene which increases resistance to Tet and Pen (as well as to other unrelated antibiotics). is a modifier gene affecting resistance to Tet and Pen. is a modifier gene for Pen resistance.

The following gene combinations code for resistance to five antibiotics: and for Tet; and for Pen: and for doxycycline; and for ampicillin; and for nafcillin.


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