SUMMARY: Oligomycin (3 μg ml) inhibited glucose utilization in S42 as shown by measurements of oxygen uptake and pyruvate production. Carbonyl cyanide 3-chloro-phenylhydrazone, an uncoupler of oxidative phosphorylation, did not relieve this inhibition, although some relief was afforded by the alternative substrate glycerol. Naturally dyskine-toplastic MIAG 105 was less sensitive to inhibition by oligomycin although glycerol relief was still observed, reflecting the differential sensitivity of the two pathways. With glucose present as the substrate, Ca transport was inhibited by oligomycin in , but was stimulated in These results are discussed in terms of alternative systems for maintaining cytoplasmic Ca concentrations in normal and dyskine-toplastic strains of trypanosome.


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