Summary: The addition of nickel ions restored urease activity and ability to grow on urea in a mutant strain of otherwise unable to utilize urea. This strain carries a mutation in the locus, one of four loci involved in urea utilization. No other urease-deficient strains tested responded to the presence of nickel ions.

The analogous characteristics of the mutant and the nitrate reductase and xanthine dehydrogenase associated mutants in are discussed. It is postulated that the locus is in some way involved in the production or incorporation of a nickel cofactor essential for urease activity.


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