Summary: Comparison of the pools of glutamic acid and glutamine and of the specific activities of glutamine synthetase and glutamate dehydrogenases in sporulating /α and non-sporulating α/α cells of revealed a difference in their nitrogen metabolism. Glutamine synthetase and glutamine appeared to be necessary for the sporulation process, glutamine playing, at least, a catabolic role. However, exogenous glutamine as well as ammonia inhibited sporulation while glutamic acid did not. Glutamine seemed to act through its amino group. Both inhibitors had at least two sites of action, one effective early in sporulation and related to DNA synthesis and the other acting later and not related to it.


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