%0 Journal Article %A Bal, Jerzy %A Kowalska, Iwona E. %A Maciejko, Dorota M. %A Węgleński, Piotr %T Allele Specific and Locus Non-specific Suppressors in Aspergillus nidulans %D 1979 %J Microbiology, %V 115 %N 2 %P 457-470 %@ 1465-2080 %R https://doi.org/10.1099/00221287-115-2-457 %I Microbiology Society, %X Using N-methyl-N′-nitro-N-nitrosoguanidine, ultraviolet irradiation, ethyl methanesul- phonate or 4-nitroquinoline-1-oxide mutagenesis and an enrichment method for the isolation of auxotrophs, 25 mutants with defects in the adA locus were obtained after screening 41376 colonies. One of these, adA24, did not complement with any of the other adA mutants, had a very high reversion rate and had some other properties which usually characterize strains carrying nonsense mutations. All revertants of adA24 carried dominant suppressor mutations. A group of adA24 suppressors was tested for allele and locus specificity. They were found to suppress only some adA alleles, and at the same time, some mutations in the methG, methH, argB and proA loci. It is proposed that the allele specific and locus nonspecific adenine suppressors are suppressors of nonsense mutations. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-115-2-457