1887

Abstract

The inhibitory effect of -lysine on penicillin biosynthesis by has been compared in a low-producing strain (Wis. 54–1255) and a high-producing strain (AS-P-78). Lysine inhibited total penicillin synthesis to a similar extent in both strains. However, in the high-producing strain the onset of penicillin synthesis occurred even at a high lysine concentration, whereas in the low-producing strain lysine had to be depleted before penicillin production commenced.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-115-1-207
1979-11-01
2022-01-19
Loading full text...

Full text loading...

/deliver/fulltext/micro/115/1/mic-115-1-207.html?itemId=/content/journal/micro/10.1099/00221287-115-1-207&mimeType=html&fmt=ahah

References

  1. Abraham E.P. 1977; β-Lactam antibiotics and related substances.. Japanese Journal of Antibiotics 30: Supplement S–21–S–26
    [Google Scholar]
  2. Boxer G.E., Everett P.M. 1949; Colorimetric determination of benzylpenicillin.. Analytical Chemistry 21:670–673
    [Google Scholar]
  3. Cooper K.E. 1972; The theory of antibiotic diffusion zones.. In Analytical Microbiology 2 pp. 13–30 Kavanagh F. Edited by London & New York: Academic Press.;
    [Google Scholar]
  4. Demain A.L. 1957; Inhibition of penicillin formation by lysine.. Archives of Biochemistry and Biophysics 67:244–245
    [Google Scholar]
  5. Demain A.L. 1974; Biochemistry of penicillin and cephalosporin fermentations.. Lloydia 37:147–166
    [Google Scholar]
  6. Demain A.L., Masurekar P.S. 1974; Lysine inhibition of in vivo homocitrate synthesis in Penicillium chrysogenum. . Journal of General Microbiology 82:143–151
    [Google Scholar]
  7. Goulden S.A., Chattaway F.W. 1969; End-product control of acetohydroxyacid synthetase by valine in Penicillium chrysogenum Q176 and a high penicillin-yielding mutant.. Journal of General Microbiology 59:111–118
    [Google Scholar]
  8. Martín J.F. 1978; Manipulation of gene expression in development of antibiotic production.. In Antibiotics and Other Secondary Metabolites: Biosynthesis and Production pp. 19–37 Hutter R., Leisinger T., Nuesch J., Wehrli W. Edited by London & New York: Academic Press.;
    [Google Scholar]
  9. Masurekar P.S., Demain A.L. 1972; Lysine control of penicillin biosynthesis.. Canadian Journal of Microbiology 18:1045–1048
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-115-1-207
Loading
/content/journal/micro/10.1099/00221287-115-1-207
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error