RT Journal Article SR Electronic(1) A1 Elliott, C. G.YR 1979 T1 Influence of the Structure of the Sterol Molecule on Sterol-induced Reproduction in Phytophthora cactorum JF Microbiology, VO 115 IS 1 SP 117 OP 126 DO https://doi.org/10.1099/00221287-115-1-117 PB Microbiology Society, SN 1465-2080, AB Production of oospores by Phytophthora cactorum in media supplemented with ten ∆5-sterols, differing in the structure of their side chains, has been measured. Spore production increased with increasing size of the substituent at C-24: H < CH3 < C2H5. A 24β-methyl group conferred greater activity than a 24β-methyl, but there was less difference between ∆5-sterols with 24β- and 24β-ethyl groups. There was a greater difference between ∆7-sterols with 24α- and 24β-ethyl substituents. A double bond at C-22 had no effect on spore production when trans, but reduced activity when cis. Four ∆7-sterols have been compared with their corresponding ∆5-sterols. Fewer oospores were produced at low concentrations (0·2 to 1 mg 1−1) of each ∆7-sterol than with the ∆5-sterol, but at higher concentrations (10 to 30 mg 1−1), the numbers with the ∆7-sterol bore no consistent relation to the numbers with the ∆5-sterol. The difference between two sterols in promoting sexual reproduction in Phytophthora cactorum is not apparently related to differences in uptake into the mycelium, or to known effects on properties of membranes, but is believed to be due to differences in metabolism of the sterols, and to differences in the hormone activity of compounds derived from them., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-115-1-117