@article{mbs:/content/journal/micro/10.1099/00221287-114-2-463, author = "Lloyd, David and Ball, Judith", title = "Perturbation of Respiration in Candida utilis: Induction of Metabolic Oscillations", journal= "Microbiology", year = "1979", volume = "114", number = "2", pages = "463-466", doi = "https://doi.org/10.1099/00221287-114-2-463", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-114-2-463", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "The effects of potentially perturbating influences on the respiration of glucose-grown Candida utilis were studied using an open oxygen electrode system. Periods of anaerobiosis as short as 2 min produced an oscillation in respiration after the air supply was restored. Longer exposure to anoxia was followed by an overshoot in dissolved oxygen after switching back to a gas phase of air. Centrifugation, cold shock or nutrient starvation caused less disturbance to respiration rates than did anaerobiosis. The high frequency oscillations (period about 5 min) resulting from anaerobic-aerobic transitions are contrasted with the slow cell cycle-dependent oscillations previously observed in synchronous cultures.", }