%0 Journal Article %A Logan, David A %A Becker, Jeffrey M. %A Naider, Fred %T Peptide Transport in Candida albicans %D 1979 %J Microbiology, %V 114 %N 1 %P 179-186 %@ 1465-2080 %R https://doi.org/10.1099/00221287-114-1-179 %I Microbiology Society, %X Summary: The tripeptide l-methionyl-l-methionyl-l-[methyl -14C]methionine was taken up into Candida albicans by a saturable system with a pH optimum of 3·5, a temperature optimum of 37 °C and an apparent K m of 33· 10−5 M. Metabolic inhibitors such as sodium azide and dinitrophenol completely prevented uptake. Neither methionine nor dimethionine effectively competed with trimethionine uptake. (Leu)3, Gly-Met-Gly, acetyl-(Met)3, D-Met-l-Met-l-Met and Met-Met-Ile effectively competed with (Met)3 uptake, whereas (Lys)3, l-Met-l-Met-d-Met, d-Met-d-Met-d-Met, (Met)3 methyl ester and (Ala)3 did not. Trimethionine was rapidly hydrolysed by a peptidase after entry into the cell. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-114-1-179