1887

Abstract

Fifty-five haemin-requiring mutants were isolated from haemin-permeable mutants. According to their growth responses to haem precursors and their patterns of porphyrin accumulation, the 55 mutants fell into three groups which were judged to have defects in 5-aminolaevulinate dehydratase, ferrochelatase, and uroporphyrinogen III cosynthase or uroporphyrinogen decarboxylase. In mutants of the group deficient in 5-aminolaevulinate dehydratase, the mutations were adjacent to , and evidence is presented that the mutations were in and were commonly deletions extending into

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1979-07-01
2021-10-24
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References

  1. Adelberg E.A., Mandel M., Chein Ching Chen G. 1965; Optimal conditions for mutagenesis by N-methyl-N-′nitro-N-nitrosoguanidine in Escherichia coli K12. Biochemical and Biophysical Research Communications 18:788–795
    [Google Scholar]
  2. Bachmann B.J., Low K.B., Taylor A.L. 1976; Recalibrated linkage map of Escherichia coli K12. Bacteriological Reviews 40:116–167
    [Google Scholar]
  3. Beljanski M., Beljanski M. 1957; Sur la formation d’enzymes respiratoires chez un mutant d’ Escherichia coli streptomycine-resistant et auxotrophe pour l’hémine. Annales de l’Institut Pasteur 92:396–412
    [Google Scholar]
  4. Broda P. 1974; Modified map positions for lac and the pro markers in Escherichia coli K12. Journal of Bacteriology 117:741–746
    [Google Scholar]
  5. Cook A., Lederberg J. 1962; Recombination studies of lactose non-fermenting mutants of Escherichia coli K12. Genetics 47:1335–1339
    [Google Scholar]
  6. Doss M. 1969; Separation, isolation and determination of proto-, copro-, pentacarboxy-, hexa-carboxy-, heptacarboxy- and uroporphyrin. Hoppe-Seyler’s Zeitschrift für physiologische. Chemie 350:499–502
    [Google Scholar]
  7. Doss M., Philipp-Dormston W.K. 1971; Porphyrin and haem biosynthesis from endogenous and exogenous 5-aminolaevulinic acid in Escherichia coli, Pseudomonas aeruginosa and Achromobacter metalcaligenes. Hoppe-Seyler’s Zeitschrift für physiologische Chemie 352:725–733
    [Google Scholar]
  8. Falk J.E. 1964 Porphyrins and Metalloporphyrins. New York: American Elsevier;
    [Google Scholar]
  9. Gibson K.D., Laver W.G., Neuberger A. 1958; Initial stages in the biosynthesis of porphyrins. Biochemical Journal 70:71–81
    [Google Scholar]
  10. Haddock B.A., Schairer H.U. 1973; Electron-transport chains of E. coli. Reconstitution of respiration in a 5-aminolaevulinic acid-requiring mutant. European Journal of Biochemistry 35:34–45
    [Google Scholar]
  11. Jacobs N.J., Jacobs J.M., Morgan H. 1972; Comparative effect of oxygen and nitrate on protoporphyrin and heme synthesis from δ-amino-laevulinic acid in bacterial cultures. Journal of Bacteriology 112:1444–1445
    [Google Scholar]
  12. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. 1951; Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193:265–275
    [Google Scholar]
  13. Markovitz A. 1964; Regulatory mechanisms for synthesis of capsular polysaccharide in mucoid mutants of Escherichia coli K12. Proceedings of the National Academy of Sciences of the United States of America 51:239–246
    [Google Scholar]
  14. Mauzerall D., Granick S. 1956; The occurrence and determination of δ-aminolevulinic acid and porphobilinogen in urine. Journal of Biological Chemistry 219:435–446
    [Google Scholar]
  15. Mcconville M.L., Charles H.P. 1975; Isolation of ‘haemin-permeable’ mutants and their use in the study of the genetics of haem biosynthesis in Escherichia coli K12. Proceedings of the Society for General Microbiology 3:14–15
    [Google Scholar]
  16. Mcconville M.L., Charles H.P. 1979a; Mutants of Escherichia coli K12 accumulating porphobilinogen: a new locus, hemC. Journal of General Microbiology 111:193–200
    [Google Scholar]
  17. Mcconville M.L., Charles H.P. 1979b; Mutants of Escherichia coli K12 permeable to haemin. Journal of General Microbiology 113:165–168
    [Google Scholar]
  18. Murphy M.J., Siegel L.M., Kamin H., Rosenthal D. 1973; Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. II. Identification of a new class of haem prosthetic group: an iron tetrahydropor-phyrin (isobacteriochlorin type) witheight carboxylie acid groups. Journal of Biological Chemistry 248:2801–2814
    [Google Scholar]
  19. Nakata A., Peterson G.R., Brooks E.L., Rothman F.G. 1971; Location and orientation of the phoA locus on the Escherichia coli K12 linkage map. Journal of Bacteriology 107:683–689
    [Google Scholar]
  20. Ornston L.N., Ornston M.K., Chou G. 1969; Isolation of spontaneous mutant strains of Pseudomonas putida. Biochemical and Biophysical Research Communications 36:179–184
    [Google Scholar]
  21. Powell K.A. 1975 Studies on the genetics and biochemistry of haem synthesis in Escherichia coli. Ph.D. thesis Reading University.:
    [Google Scholar]
  22. Săsărman A., Horodniceanu T. 1967; Locus determining normal colony formation on the chromosome of Escherichia coli K12. Journal of Bacteriology 94:1268–1269
    [Google Scholar]
  23. Săsărman A., Surdeanu M., Szégli G., Horodniceanu T., Greceanu V., Dumitrescu A. 1968; Hemin-deficient mutants of Escherichia coli K12. Journal of Bacteriology 96:570–572
    [Google Scholar]
  24. Siegel L.M., Davis P.S., Murphy M.J. 1977; Incorporation of methionine-derived methyl groups into sirohaem by Escherichia coli. Biochemical Journal 167:669–674
    [Google Scholar]
  25. Taylor A.L., Trotter C.D. 1972; Linkage map of Escherichia coli strain K12. Bacteriological Reviews 36:504–524
    [Google Scholar]
  26. Tien W., White D.C. 1968; Linear sequential arrangement of genes for the biosynthetic pathway of protoheme in Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America 61:1392–1398
    [Google Scholar]
  27. Vogel H.J., Bonner D.M. 1956; A convenient growth medium for Escherichia coli and some other micro-organisms (medium E). Microbial Genetics Bulletin 13:43–44
    [Google Scholar]
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