Summary: , an extremely halophilic bacterium, lacks a normal peptidoglycan cell wall. Nevertheless, bacitracin, a known inhibitor of peptidoglycan synthesis, has been shown to completely suppress the growth of this organism (Mescher & Strominger, 1975) In an attempt to clarify this observation, the effect of bacitracin on DNA, RNA, protein and lipid biosynthesis in was monitored. Lipid carbohydrate and lipid phosphate were the most affected. These observations were confirmed by uptake studies of [glycerol into the membrane lipids. The possibility that bacitracin acts against through inhibition of dephosphorylation of the isoprenoid pyrophosphate precursors of this organism's diether lipids is discussed.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error