1887

Abstract

SUMMARY: When ingested by mouse peritoneal macrophage monolayers, live caused a sustained increase in monolayer cyclic AMP content and fusion of lysosomes with the bacterium-containing phagosomes was impaired. Ingested live BCG caused a transient increase in cyclic AMP and the defect in phagolysosome formation was less pronounced. Dead mycobacteria and live neither enhanced monolayer cyclic AMP content nor inhibited phagolysosome formation. and BCG exceeded in cyclic AMP-synthesizing activity but the question of whether bacterial cyclic AMP contributed substantially to the increments in infected macrophages was not resolved. Antibody-coated BCG retained the ability to synthesize cyclic AMP and to enhance monolayer cyclic AMP but lost the ability to inhibit phagolysosome formation in macrophages. The observations are discussed in terms of possible control of phagolysosome formation by cyclic nucleotides.

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1979-02-01
2024-04-19
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References

  1. Abdou N. I., Na Pombejara C., Sagawa A., Ragland C., Stechschulte D. J., Nilsson U., Gourley W., Watanabe I., Lindsey N. J., Allen M. S. 1977; Malakoplakia: evidence for monocyte lysosomal abnormality correctable by cholinergic agonist in vitro and in vivo. New England Journal of Medicine 297:1413–1419
    [Google Scholar]
  2. Ackerman N. R., Beebe J. R. 1975; Effects of pharmacologic agents on release of lysosomal enzymes from alveolar mononuclear cells. Journal of Pharmacology and Experimental Therapeutics 193:603–613
    [Google Scholar]
  3. Appleman M. M., Thompson W. J., Russell T. R. 1973; Cyclic nucleotide phosphodiesterases. Advances in Cyclic Nucleotide Research 3:65–98
    [Google Scholar]
  4. Armstrong J. A., Hart P. D’A. 1971; Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes. Journal of Experimental Medicine 134:713–740
    [Google Scholar]
  5. Armstrong J. A., Hart P. D’A. 1975; Phagosome–lysosome interactions in cultured macrophages infected with virulent tubercle bacilli: reversal of the usual nonfusion pattern and observations on bacterial survival. Journal of Experimental Medicine 142:1–16
    [Google Scholar]
  6. Atkinson J. P., Wedner H. J., Parker C. W. 1975; Two novel stimuli of cyclic adenosine 3ʹ,5ʹ-monophosphate (cAMP) in human lymphocytes. Journal of Immunology 115:1023–1027
    [Google Scholar]
  7. Boxer L. A., Watanabe A. M., Rister M., Besch H. R., Allen J., Baehner R. L. 1976; Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate. New England Journal of Medicine 295:1041–1045
    [Google Scholar]
  8. Boxer L. A., Rister M., Allen J. M., Baehner R. L. 1977; Improvement of Chediak-Higashi leukocyte function by cyclic guanosine monophosphate. Blood 49:9–17
    [Google Scholar]
  9. Carrol M. E. W., Jackett P. S., Aber V. R., Lowrie D. B. 1979; Phagolysosome formation, cyclic adenosine 3ʹ:5ʹ-monophosphate and the fate of Salmonella typhimurium within mouse peritoneal macrophages. Journal of General Microbiology 110:421–429
    [Google Scholar]
  10. Davies W. A., Stossel T. P. 1977; Peripheral hyaline blebs (podosomes) of macrophages. Journal of Cell Biology 75:941–955
    [Google Scholar]
  11. Gemsa D., Woo C. H., Webb D., Fudenberg H. H., Schmid R. 1975a; Erythrophagocytosis by macrophages: suppression of heme oxygenase by cyclic AMP. Cellular Immunology 15:21–36
    [Google Scholar]
  12. Gemsa D., Steggemann L., Menzel J., Till G. 1975b; Release of cyclic AMP from macrophages by stimulation with prostaglandins. Journal of Immunology 114:1422–1424
    [Google Scholar]
  13. Goren M. B., Hart P. D’A.,, Young M. R., Armstrong J. A. 1976; Prevention of phagosome–lysosome fusion in cultured macrophages by sulfatides of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America 73:2510–2514
    [Google Scholar]
  14. Hanks J. H. 1968; Metabolism of in vivo grown mycobacteria. Annals of the New York Academy of Sciences 154:68–78
    [Google Scholar]
  15. Hart P. D’A.,, Armstrong J. A., Brown C. A., Draper P. 1972; Ultrastructural study of the behavior of macrophages toward parasitic mycobacteria. Infection and Immunity 5:803–807
    [Google Scholar]
  16. Henson P. 1974; Mechanism of mediator release from inflammatory cells. In Mediators of Inflammation, pp. 9–50 Edited by Weissmann G. New York: Plenum Press;
    [Google Scholar]
  17. Ignarro L. J. 1975; Regulation of lysosomal enzyme release by prostaglandins, autonomic neurohormones and cyclic nucleotides.. In Lysosomes in Biology and Pathology, vol. 4 , pp. 481–523 Edited by Dingle J. T., Dean R. T. Amsterdam: North Holland;
    [Google Scholar]
  18. Ignarro L. J., George W. J. 1974; Mediation of immunologic discharge of lysosomal enzymes from human neutrophils by guanosine 3ʹ5ʹ-monophosphate. Requirement for calcium and inhibition by adenosine 3ʹ,5ʹ-monophosphate. Journal of Experimental Medicine 140:225–238
    [Google Scholar]
  19. Jones T. C., Hirsch J. G. 1972; The interaction between Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. Journal of Experimental Medicine 136:1173–1194
    [Google Scholar]
  20. Long E. R. 1958 The Chemistry and Chemotherapy of Tuberculosis, 3rd edn p. 11. Baltimore: Williams & Wilkins;
    [Google Scholar]
  21. Lowrie D. B. 1976; A device for automatic measurement of very low liquid flow rates. Analytical Biochemistry 76:32–36
    [Google Scholar]
  22. Lowrie D. B., Jackett P. S., Ratcliffe N. A. 1975; Mycobacterium microti may protect itself from intracellular destruction by releasing cyclic AMP into phagosomes. Nature, London 254:600–602
    [Google Scholar]
  23. Lowrie D. B., Aber V. R., Carrol M. E. W. 1979; Division and death rates of Salmonella typhimurium inside macrophages: use of penicillin as a probe. Journal of General Microbiology 110:409–419
    [Google Scholar]
  24. Manganiello V., Evans W. H., Stossel T. P., Mason R. J., Vaughan M. 1971; The effect of polystyrene beads on cyclic 3ʹ,5ʹ-adenosine monophosphate concentration in leukocytes. Journal of Clinical Investigation 50:2741–2744
    [Google Scholar]
  25. Oliver J. M., Zurier R. B. 1976; Correction of characteristic abnormalities of microtubule function and granule morphology in Chediak-Higashi syndrome with cholinergic agonists: studies in vitro in man and in vivo in the beige mouse. Journal of Clinical Investigation 57:1239–1247
    [Google Scholar]
  26. Oliver J. M., Krawiec J. A., Berlin R. D. 1976; Carbamylcholine prevents giant granule formation in cultured fibroblasts from beige (Chediak-Higashi) mice. Journal of Cell Biology 69:205–210
    [Google Scholar]
  27. Perkins J. P. 1973; Adenyl cyclase. Advances in Cyclic Nucleotide Research 3:1–64
    [Google Scholar]
  28. Schmidt-Gayk H. E., Jakobs K. H., Hackenthal E. 1975; Cyclic AMP and phagocytosis in alveolar macrophages: influence of hormones and dibutyryl cyclic AMP. Journal of the Reticuloendothelial Society 17:251–261
    [Google Scholar]
  29. Seyberth H. W., Schmidt-Gayk H., Jakobs K. H., Hackenthal E. 1973; Cyclic adenosine monophosphate in phagocytizing granulocytes and alveolar macrophages. Journal of Cell Biology 57:567–571
    [Google Scholar]
  30. Tempest D. W. 1970; The continuous cultivation of micro-organisms. I. Theory of the chemostat. Methods in Microbiology 2:259–276
    [Google Scholar]
  31. Weissmann G., Dukor P., Zurier R. B. 1971; Effect of cyclic AMP on release of lysosomal enzymes from phagocytes. Nature New Biology 231:131–135
    [Google Scholar]
  32. Weissmann G., Goldstein I., Hoffstein S., Chauvet G., Robineaux R. 1975; Yin/Yang modulation of lysosomal enzyme release from polymorphonuclear leukocytes by cyclic nucleotides. Annals of the New York Academy of Sciences 256:222–231
    [Google Scholar]
  33. Welscher H. D., Cruchaud A. 1976; The influence of various particles and 3ʹ,5ʹ-cyclic adenosine monophosphate on release of lysosomal enzymes by mouse macrophages. Journal of the Reticuloendothelial Society 20:405–420
    [Google Scholar]
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