1887

Abstract

SUMMARY: Histidine-independent (h) mutants induced in histidine-requiring (h) cultures by ultraviolet light have a delay in the onset of logarithmic increase that is about two generations longer than the delay shown by marked unirradiated h bacteria present at the same time. This extra delay is interpreted as being due to the segregation of one from four nuclei which are present, on the average, in growing h organisms. The same assumption accounts for the extra delay observed in spontaneous h mutants. These and other results are discussed in relation to the site of mutation and to the various types of delay that can retard the onset of growth of a mutant clone. It is concluded that in the mutation from h to h, the h condition is dominant in the heterocaryon, that whatever phenotypic delay exists is short, and that cell division is not required to pass through it.

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/content/journal/micro/10.1099/00221287-11-3-380
1954-12-01
2019-12-06
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