SUMMARY: Shigella phage S13 and coli phage T3 are very sensitive, in the free state, to inactivation by reducing radicals produced in water by ionizing radiation. They are inactivated by ascorbic acid, and by hydrogen peroxide (HO) acting as a reductant; but the HO must decompose into active radicals before it attacks the phage. Hydrogen peroxide decomposes under irradiation, and attacks phage much more vigorously under ionizing radiation than under ultraviolet irradiation. Free radicals may part-inactivate phage, that is, render it more sensitive to HO and to ascorbic acid, though not to inactivating agents in general. Phage grown on rich medium is more sensitive than phage grown on poor medium to inactivation by reduction.


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