@article{mbs:/content/journal/micro/10.1099/00221287-11-2-250, author = "Clowes, R. C. and Rowley, D.", title = "Some Observations on Linkage Effects in Genetic Recombination in Escherichia coli K-12", journal= "Microbiology", year = "1954", volume = "11", number = "2", pages = "250-260", doi = "https://doi.org/10.1099/00221287-11-2-250", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-11-2-250", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "SUMMARY: Further recombination data have been obtained from matings involving different F+ auxotrophic mutants of Escherichia coli strain K-12 with the same K-12 F− auxotroph. Variations in the distribution of sugar fermentation markers among the progeny have been explained by the influence of the ‘contra-selected’ F+ auxotrophic marker. It is suggested that the data supports the conception of a single linear chromosome in K-12, which fragments randomly during recombination.", }