A variant of 15, strain GU1, was isolated on the basis of its resistance to phage °CbK. Strain GU1 was also resistant to phages °Cb12r and °Cb13, developed filaments in liquid culture and showed altered sensitivity to the inhibitors methylene blue, sodium deoxycholate and ampicillin. Analysis by sodium dodecyl sulphate-polyacrylamide gel electrophoresis of the membranes of strains 15 and 1 showed major differences. Partial revertants of the 1 phenotype were isolated in which only the inhibitor sensitivities were changed. The origin of these partial revertants was investigated by the fluctuation analysis of Luria & Delbruck (1943). The results suggest that these partial revertants, which were stably inherited, were non-random in origin.


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