1887

Abstract

R plasmids pMG1, R2, R931 and pMG15 increased the survival of exposed to ultraviolet radiation (u.v.) in the wild type, and and mutants but did not alter the u.v.-response of a mutant. The R plasmid RPL11 reduced u.v.-survival in the wild type, and and mutants but did not alter the u.v.-response of a host. All the plasmids enhanced the level of spontaneous and u.v.-induced back mutation (Trp) in a strain.

The effect of a sublethal concentration of sodium arsenite following u.v.-irradiation was examined. It was concluded that in strains (pMG1) and (R931), u.v.-protection is determined by a -dependent, arsenite-sensitive repair pathway, whereas in strains (R2) and (pMG15), u.v.-protection is determined by a -dependent, arsenite-insensitive step in DNA repair.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-108-1-119
1978-09-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/micro/108/1/mic-108-1-119.html?itemId=/content/journal/micro/10.1099/00221287-108-1-119&mimeType=html&fmt=ahah

References

  1. Calhoun D. H., Pierson D. L., Jensen R. A. 1973; The regulation of tryptophan biosynthesis in Pseudomonas aeruginosa. Molecular and General Genetics 121:117–132
    [Google Scholar]
  2. Chandler P. M., Krishnapillai V. 1974; Isolation and properties of recombination-deficient mutants of Pseudomonas aeruginosa. Mutation Research 23:15–23
    [Google Scholar]
  3. Crawford I. P. 1975; Gene rearrangements in the evolution of the tryptophan synthetic pathway. Bacteriological Reviews 39:87–120
    [Google Scholar]
  4. Falkiner F. R., Keane C. T., Dalton M., Clancy M. T., Jacoby G. A. 1977; Cross infection in a surgical ward caused by Pseudomonas aeruginosa with transferable resistance to gentamicin and tobramycin. Journal of Clinical Pathology 33:731–736
    [Google Scholar]
  5. Jacoby G. A. 1974; Property of R plasmids determining gentamicin resistance by acetylation in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 6:239–252
    [Google Scholar]
  6. Kawakami Y., Mikoshiba F., Nagasaki S., Matsuomoto H., Tazaki T. 1972; Prevalence of Pseudomonas aeruginosa strains possessing R factor in a hospital. Journal of Antibiotics 25:607–609
    [Google Scholar]
  7. Korfhagen T. R., Loper J. C. 1975; RPL11, an R factor of Pseudomonas aeruginosa determining carbenicillin and gentamicin resistance. Antimicrobial Agents and Chemotherapy 7:69–73
    [Google Scholar]
  8. Krishnapillai V. 1975; Resistance to ultraviolet light and enhanced mutagenesis conferred by Pseudomonas aeruginosa plasmids. Mutation Research 29:363–372
    [Google Scholar]
  9. Kung A. H. C., Lee B. T. O. 1973; The isolation and survival characteristics of radiation and chemical mutagen sensitive mutants of Pseudomonas aeruginosa. Mutation Research 20:175–190
    [Google Scholar]
  10. Lehrbach P., Kung A. H. C., Lee B. T. O. 1976; Mutants of Pseudomonas aeruginosa deficient in DNA polymerase I. Mutation Research 41:391–394
    [Google Scholar]
  11. Lehrbach P., Kung A. H. C., Lee B. T. O., Jacoby G. A. 1977a; Plasmid modification of radiation and chemical-mutagen sensitivity in Pseudomonas aeruginosa. Journal of General Microbiology 98:167–176
    [Google Scholar]
  12. Lehrbach P., Kung A. H. C., Lee B. T. O. 1977b; Loss of ultraviolet light protection and enhanced ultraviolet light-induced mutability in Pseudomonas aeruginosa carrying mutant R plasmids. Journal of General Microbiology 101:135–141
    [Google Scholar]
  13. Rossman T., Meyn M. S., Troll W. 1975; Effects of sodium arsenite on the survival of UV-irradiated Escherichia coli: inhibition of a recA-dependent function. Mutation Research 30:157–162
    [Google Scholar]
  14. Rossman T. G., Meyn M. S., Troll W. 1977; Effects of arsenite on DNA repair in Escherichia coli. Environmental Health Perspectives (in the Press)
    [Google Scholar]
  15. Tseng J. T., Bryan L. E. 1973; Mechanisms of R factor R931 and chromosomal tetracycline resistance in Pseudomonas aeruginosa. Anti-microbial Agents and Chemotherapy 3:638–641
    [Google Scholar]
  16. Witkin E. M. 1976; Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. Bacteriological Reviews 40:869–907
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-108-1-119
Loading
/content/journal/micro/10.1099/00221287-108-1-119
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error