1887

Abstract

At sub-bactericidal concentrations of hydrogen peroxide, was killed by hydrogen peroxide/peroxidase/halide microbicidal systems. The halide cofactor could be either iodide or, with much lower efficiency, chloride. Omission of any one of the reactants eliminated the tuberculocidal effect. Differences in susceptibility between different strains of did not correlate with virulence differences. The observations are discussed in the context of host defence mechanisms against tuberculosis.

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1978-08-01
2021-08-05
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References

  1. Avila J. L., Convit J., Plnardi M. E., Jacques P. J. 1976; Loss of infectivity of mycobacterial and protozoal exoplasmic parasites after exposure in vitro to the polyenzymic cocktail ‘PIGO’. Biochemical Society Transactions 4:680–681
    [Google Scholar]
  2. Biggar W. D., Sturgess J. M. 1976; Peroxidase activity of alveolar macrophages. Laboratory Investigation 34:31–42
    [Google Scholar]
  3. Biggar W. D., Buron S., Holmes B. 1976; Bactericidal mechanisms in rabbit alveolar macrophages : evidence against peroxidase and hydrogen peroxide bactericidal mechanisms. Infection and Immunity 14:6–10
    [Google Scholar]
  4. Bloch R. G. 1963; The affect of hyperthyroidism on tuberculosis in the guinea-pig: a possible approach to experimental sarcoidosis. American Review of Respiratory Diseases 87:525–528
    [Google Scholar]
  5. Daems W. Th., Wisse P., Brederoo P., Emeis J. J. 1975; Peroxidatic activity in monocytes and macrophages. Mononuclear Phagocytes in Immunity, Infection and Pathology57–77 van Furth R. Oxford: Blackwell Scientific;
    [Google Scholar]
  6. Dannenberg A. M., Ando M., Shima K. 1972; Macrophage accumulation, division, maturation and digestive and microbicidal capacities in tuberculous lesions. III. The turnover of macro-phages and its relation to their activation and antimicrobial immunity in primary BCG lesions and those of reinfection. Journal of Immunology 109:1109–1121
    [Google Scholar]
  7. Delville J., Huybrechts-Godin G., Jacques P. J. 1976; Germicidal activity of the PIGO system on Mycobacterium leprae, in vitro . Archives internationales de physiologie et de biochimie 84:604–605
    [Google Scholar]
  8. Demoulin-Brahy L., Paulus A., Huybrechts-Godin G., Jacques P. J. 1975; Germicidal activity of a polyenzymic system on various exoplasmic parasites in vitro . Journal of the Reticuloendothelial Society 18:14a
    [Google Scholar]
  9. Draper P., Hart P. D’A. 1975; Phagosomes, lysosomes and mycobacteria : cellular and microbial aspects. Mononuclear Phagocytes in Immunity, Infection and Pathology575–589 van Furth R. Oxford: Blackwell Scientific;
    [Google Scholar]
  10. Hsu H.-S., Kapral F. A. 1960; The suppressed multiplication of tubercle bacilli within macro-phages derived from triiodothyronine-treated guinea-pigs. American Review of Respiratory Diseases 81:881–887
    [Google Scholar]
  11. Jackett P. S., Aber V. R., Lowrie D. B. 1978; Virulence and resistance to superoxide, low pH and hydrogen peroxide among strains of Mycobacterium tuberculosis . Journal of General Microbiology 104:37–15
    [Google Scholar]
  12. Klebanoff S. J. 1965; Inactivation of estrogen by rat uterine preparations. Endocrinology 76:301–311
    [Google Scholar]
  13. Klebanoff S. J. 1967; Iodination of bacteria: a bactericidal mechanism. Journal of Experimental Medicine 126:1063–1078
    [Google Scholar]
  14. Klebanoff S. J. 1970; Myeloperoxidase-mediated antimicrobial systems and their role in leukocyte function. Biochemistry of the Phagocytic Process89–110 Schultz G.J. Amsterdam and London: North-Holland;
    [Google Scholar]
  15. Klebanoff S. J. 1975; Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes. Seminars in Haematology 12:117–142
    [Google Scholar]
  16. Klebanoff S. J., Hamon C. B. 1972; Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes. Journal of the Reticuloendothelial Society 12:170–196
    [Google Scholar]
  17. Klebanoff S. J., Hamon C. B. 1975; Antimicrobial systems of mononuclear phagocytes. Mononuclear Phagocytes in Immunity, Infection and Pathology507–529 van Furth R. Oxford: Blackwell Scientific;
    [Google Scholar]
  18. Klebanoff S. J., Luebke R. G. 1965; The anti-lactobacillus system of saliva. Role of salivary peroxidase. Proceedings of the Society for Experimental Biology and Medicine 118483–486
    [Google Scholar]
  19. Lehrer R. I. 1970; The fungicidal activity of human monocytes: a myeloperoxidase-linked mechanism. Clinical Research 18:408
    [Google Scholar]
  20. Lepper A.W.D., Hart P. D’A. 1976; Peroxidase staining in elicited and nonelicited mononuclear peritoneal cells from BCG-sensitized and nonsensitized mice. Infection and Immunity 14:522–526
    [Google Scholar]
  21. Lowrie D. B., Jackett P. S., Ratcliffe N. A. 1975; Mycobacterium microti may protect itself from intracellular destruction by releasing cyclic AMP into phagosomes. Nature London: 254600–602
    [Google Scholar]
  22. Lurie M. B. 1964 Resistance to Tuberculosis: Experimental Studies in Native and Acquired Defensive Mechanisms Cambridge, Massachusetts: Harvard University Press;
    [Google Scholar]
  23. Meynell G. G. 1961; Phenotypic variation in bacterial infection. Symposia of the Society for General Microbiology 11:174–195
    [Google Scholar]
  24. Mitchison D. A., Selkon J. B., Lloyd J. 1963; Virulence in the guinea-pig, susceptibility to hydrogen peroxide, and catalase activity of isoniazid-sensitive tubercle bacilli from South Indian and British patients. Journal of Pathology and Bacteriology 86:377–386
    [Google Scholar]
  25. Nodine J. H., Yoshizawa H., Weiss W., Stein S. C., Guth R., Tummillio M. 1959; The effect of L-triiodothyronine in pulmonary tuberculosis : a pilot study. American Journal of Medical Sciences 237:27–41
    [Google Scholar]
  26. Reiter B., Pickering A., Oram J. D. 1964; An inhibitory system - lactoperoxidase, thiocyanate, peroxide-in raw milk. 4th International Symposium on Food Microbiology297–305 Molin N. Stockholm: Almqvist and Wiksell;
    [Google Scholar]
  27. Sbarra A. J., Selvaraj R. J., Paul B. B., Zgliczynski J. M., Poskitt P. K. F., Mitchell G. W., Louis F. 1976; Chlorination, de-carboxylation and bactericidal activity mediated by the MPO-H2O2-C1-system. The Reticuloendothelial System in Health and Disease191–203 Reichard S. M., Escobar M. R., Friedman H. New York and London: Plenum Press;
    [Google Scholar]
  28. Sbarra A. J., Selvaraj R. J., Paul B. B., Poskitt P. K. F., Mitchell G. W., Louis F., Asbell M. A. 1977; Granulocyte biochemistry and a hydrogen peroxide-dependent micro-bicidal system. The Granulocyte: Function and Clinical Utilization29–48 Greenwalt T. J., Jamieson G. A. New York: A. R. Liss;
    [Google Scholar]
  29. Spector W. G. 1975; The dynamics of granulomas and the significance of epithelioid cells. Pathologie et biologie 23:437–439
    [Google Scholar]
  30. Winslow C.-E., Walker H. H. 1939; The earlier phases of the growth cycle. Bacteriological Reviews 3:147–186
    [Google Scholar]
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