Observations by phase contrast, fluorescence and electron microscopy showed that epimastigotes of (grown ) were phagocytosed posterior end first by mouse peritoneal macrophages Many were subsequently digested as a result of phagosome-lysosome fusion but others survived by apparently inhibiting this fusion and/or escaping from the phagosome into the host cell's cytoplasm. These survivors replicated as amastigotes. Long trypomastigotes, separated from populations grown by passage down a column of glass beads (with or without prior exposure to guinea-pig serum), were phagocytosed by either pole and all were subsequently digested.


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