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A plasmid (SRP1) determines most of the genetic recombination which occurs between marked derivatives of our strain of Streptomyces rimosus. SRP1? strains occur with a frequency of about 0.3% amongst spores of SRP1 + strains. In SRP1 +xSRP1 ? crosses, SRP1 is transferred to more than 50% of the SRP1 ? parent. SRP1 +xSRP1 ? crosses are about 100 times more fertile than SRP1+xSRP1+ crosses (10?3 to 10?4 compared with 10?5 to 10?7). A very low frequency (about 10?8) of true recombinants occurs in the absence of SRP1.
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