1887

Abstract

Thirty-two clinical isolates of anthropophilic dermatophytes were examined for their capacity to produce antibiotics in liquid culture and on human stratum corneum Antibiotics were detected and classified using agar diffusion bioassays and chromatographic analysis. Twenty-four isolates produced antibiotic substances in liquid culture filtrates; some strains produced more than one antibiotic. Only four isolates produced detectable levels of antibiotics when grown on stratum corneum unless an artificial sweat mixture was used as a nutrient supplement, when the number rose to 11. Representatives of all species studied produced benzyl penicillin-like substances. Some Trichophyton isolates also produced streptomycin-like antibiotics, a characteristic previously unrecorded for eukaryotic organisms. Other antibiotics, which apart from azalomycin F could not be properly classified, were produced by Antibiotic production occurred over the normal skin temperature range but sometimes the type of antibiotic produced and the frequency of detection appeared to be influenced by the incubation temperature.

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1978-03-01
2021-05-11
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References

  1. Allen A. M., Taplin D. 1974; Skin infections in eastern Panama. Survey of two representative communities. American Journal of Tropical Medicine and Hygiene 23:950–956
    [Google Scholar]
  2. Betina V. 1964; A systematic analysis of antibiotics using paper chromatography. Journal of Chromatography 15:379–392
    [Google Scholar]
  3. Bibel D. J., Le Brun J. R. 1975; Effect of experimental dermatophyte infection on cutaneous flora. Journal of Investigative Dermatology 64:119–123
    [Google Scholar]
  4. Blum G., De Weck A. L. 1966; Über den Zusammenhang von Dermatomykosen mit der Penicillinüberempfindlichkeit. Dermatologica 133:461–472
    [Google Scholar]
  5. Bolgar E., Fehér E., Török H., Rajka E. 1960; Über Penicillinallergie. Hautarzt 11:254–258
    [Google Scholar]
  6. Cole D. S., Holt G., Macdonald K. D. 1976; Relationship of the genetic determination of impaired penicillin production in naturally occurring strains to that in induced mutants of Aspergillus nidulans. Journal of General Microbiology 96:423–426
    [Google Scholar]
  7. Cole M. 1966; Formation of 6-aminopenicillanic acid, penicillins and penicillin acylase by various fungi. Applied Microbiology 14:88–104
    [Google Scholar]
  8. Gip L., Palsson G. 1970a; Production of antibiotics by geophilic dermatophytes. I. Screening test of antibacterial activity. Mykosen 13:397–400
    [Google Scholar]
  9. Gip L., Palsson G. 1970b; Production of antibiotics by geophilic dermatophytes. II. Antibiotic spectrum of crude filtrates. Mykosen 13:521–523
    [Google Scholar]
  10. Holt G., Macdonald K. D. 1968; Penicillin production and its mode of inheritance in Aspergillus nidulans. Antonie van Leeuwenhoek 34:409–416
    [Google Scholar]
  11. Honda S. 1936; Über das antagonistische Phaenomen zwischen verschiedenen pathogenen Schimmelpilzen und Bakterien. Japanese Journal of Dermatology 39:97–98
    [Google Scholar]
  12. Knight A. G. 1972; Culture of dermatophytes upon stratum corneum. Journal of Investigative Dermatology 59:427–431
    [Google Scholar]
  13. Marples M. J., Bailey M. J. 1957; A search for the presence of pathogenic bacteria and fungi in the interdigital spaces of the foot. British Journal of Dermatology 69:379–388
    [Google Scholar]
  14. Murphy C. T. 1975; Nutrient materials and the growth of bacteria on human skin. Transactions. St John’s Hospital Dermatological Society: 6151–57
    [Google Scholar]
  15. Nakamura T. 1932; Über die antagonistische Wirkung des Trichophytonpilzes gegen Heubazillus. Japanese Journal of Dermatology 32:126
    [Google Scholar]
  16. Nishio K. 1958; Epidermophyton inguinale in der Antibioticum-Forschung. Japanese Journal of Dermatology 20:221–239
    [Google Scholar]
  17. Noble W. C. 1977; Variation in the prevalence of antibiotic resistance of Staphylococcus aureus from human skin and nares. Journal of General Microbiology 98:125–132
    [Google Scholar]
  18. Noble W. C., Somerville D. A. 1974 Microbiology of Human Skin. London: W. B. Saunders;
    [Google Scholar]
  19. Peck S. M., Hewitt W. L. 1945; The production of an antibiotic substance similar to penicillin by pathogenic fungi. Public Health Reports 60:148–193
    [Google Scholar]
  20. Raper K. B., Alexander D. F., Coghill R. D. 1944; Penicillin. II. Natural variation and penicillin production in Pnicillium notatum and allied species. Journal of Bacteriology 48:639–659
    [Google Scholar]
  21. Schuppli R. 1962; Über den Zusammenhang zwischen Penicillinallergie und Pilzinfektionen. Deutsche medizinische Wochenschrift 87:333–335
    [Google Scholar]
  22. Selwyn S. 1975; Natural antibiosis among skin bacteria as a primary defence against infection. British Journal of Dermatology 93:487–493
    [Google Scholar]
  23. Smith J. M. B., Marples M. J. 1964; A natural reservoir of penicillin-resistant strains of Staphylococcus aureus. Nature; London: 201844
    [Google Scholar]
  24. Uri J., Valu G., Békési I. 1963; Production of 6-a.p.a. by dermatophytes. Nature; London: 200896–897
    [Google Scholar]
  25. Wallerstrom A. 1967; Production of antibiotics by Epidermophyton floccosum. 1. The antibiotic spectrum of crude filtrates. Acta pathologica et microbiologica scandinavica 71:287–295
    [Google Scholar]
  26. Wallerstrom A. 1968; Production of antibiotics by Epidermophyton floccosum. 2. Microflora in Epidermophyton-infected skin and its resistance to antibiotics produced by the fungus. Acta pathologica et microbiologica scandinavica 74:531–542
    [Google Scholar]
  27. Wallerstrom A. 1969; Production of antibiotics by Epidermophyton floccosum. 3. Course of fermentation and some properties of the epidermophyton factor (E.P.F.). Acta pathologica et microbiologica scandinavica 75:435–146
    [Google Scholar]
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