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Abstract
Saccharomyces cerevisiae can accommodate to the presence of toxic levels of Cd2+. This adaptation can also be induced, though to a lesser degree, by pre-growth of the yeast in 50 μ m-Zn2+. Growth of Cd2+-adapted yeast through several passages in Cd2+-free medium leads to a progressive decrease in Cd2+-tolerance by the yeast, suggesting that the adaptation did not involve selection of a Cd2+-resistant mutant. Chromatography on Sephadex G-75 of the soluble fraction from Cd2+-adapted yeast indicated that no metallothionein-like protein was present. This suggests that the mechanism of adaptation is unlike that of the higher eukaryotes.
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© Society for General Microbiology 1978