1887

Abstract

SUMMARY: Arginine and glutamine, which prevents the catabolism of arginine, are accumulated when conidia of auxotrophic mutants of are deprived of an amino acid. This accumulation requires sources of carbon and nitrogen, an intact arginine biosynthetic pathway, synthesis of pyrimidines and protein synthesis. There is coordination between the synthesis of glutamine and the synthesis and catabolism of arginine. Conditions which allow these amino acids to accumulate prevent exogenous arginine from being catabolized.

Since more than half of the accumulated amino nitrogen is stored as glutamine and arginine, it is proposed that these amino acids are nitrogen and/or carbon reservoirs under non-growth conditions.

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/content/journal/micro/10.1099/00221287-104-2-233
1978-02-01
2022-01-27
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References

  1. Carsiotis M., Jones R. F. 1974; Cross-pathway regulation: tryptophan-mediated control of histidine and arginine biosynthetic enzymes in Neurospora crassa. Journal of Bacteriology 119:889–892
    [Google Scholar]
  2. Carsiotis M., Jones R. F., Wesseling A. C. 1974; Cross-pathway regulation: histidinemediated control of histidine, tryptophan, and arginine biosynthetic enzymes in Neurospora crassa. Journal of Bacteriology 119:893–898
    [Google Scholar]
  3. Castañeda M., Martuscelli J., Mora J. 1967; The catabolism of l-arginine by Neurospora crassa. Biochimica et biophysica acta 141:276–282
    [Google Scholar]
  4. Chinard F. P. 1952; Photometric estimation of proline and ornithine. Journal of Biological Chemistry 199:91–95
    [Google Scholar]
  5. Davis R. H., Mora J. 1968; Mutants of Neurospora crassa deficient in ornithine-δ-transaminase. Journal of Bacteriology 96:383–388
    [Google Scholar]
  6. Davis R. H., Lawless M. B., Port L. A. 1970; Arginaseless Neurospora: genetics, physiology and polyamine synthesis. Journal of Bacteriology 102:299–305
    [Google Scholar]
  7. Delforge J., Messenguy F., Waime J. M. 1975; The regulation of arginine biosynthesis in Saccharomyces cerevisiae. The specificity of arg R mutations and the general control of amino acid biosynthesis. European Journal of Biochemistry 57:231–239
    [Google Scholar]
  8. Ferguson A. R., Sims A. P. 1974; The regulation of glutamine metabolism in Candida utilis: the role of glutamine in the control of glutamine synthetase. Journal of General Microbiology 80:159–171
    [Google Scholar]
  9. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. 1951; Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193:265–275
    [Google Scholar]
  10. Mora J., Salceda R., Sánchez S. 1972; Regulation of arginase activity by intermediates of the arginine biosynthetic pathway in Neurospora crassa. Journal of Bacteriology 110:870–877
    [Google Scholar]
  11. Mora Y., Espín G., Willms K., Mora J. 1978; Nitrogen accumulation in mycelium of Neurospora crassa. Journal of General Microbiology 104:241–250
    [Google Scholar]
  12. Pall M. L. 1969; Amino acid transport in Neurospora crassa. I. Properties of two amino acid transport systems. Biochimica et biophysicaacta 173:113–127
    [Google Scholar]
  13. Pall M. L. 1970; Amino acid transport in Neurospora crassa. II. Properties of a basic amino acid transport system. Biochimica et biophysica acta 203:139–149
    [Google Scholar]
  14. Sánchez S., Martínez L., Mora J. 1972; Interactions between amino acid transport systems in Neurospora crassa. Journal of Bacteriology 112:276–284
    [Google Scholar]
  15. Schurch A., Miozzari J., Hutter R. 1974; Regulation of tryptophan biosynthesis in Saccharomyces cerevisiae: mode of action of 5-methyl tryptophan sensitive mutants. Journal of Bacteriology 227:1131–1140
    [Google Scholar]
  16. Vaca G., Mora J. 1977; Nitrogen regulation of arginase in Neurospora crassa. Journal of Bacteriology 131:719–725
    [Google Scholar]
  17. Van Pilsum J. F., Martin R. P., Kito E., Hess J. 1956; Determination of creatine, creatinine, arginine, guanido-acetic acid, guanidine and methyl-guanidine in biological fluids. Journal of Biological Chemistry 222:225–236
    [Google Scholar]
  18. Vogel H. J. 1964; Distribution of lysine pathways among fungi: evolutionary implications. American Naturalist 98:435–446
    [Google Scholar]
  19. Vogel H. J., Bonner D. M. 1954; On the glutamate-proline-ornithine inter-relation in Neurospora crassa. Proceedings of the National Academy of Sciences of the United States of America 40688–694
    [Google Scholar]
  20. Weiss R. L. 1973; Intracellular localization of ornithine and arginine pools in Neurospora. Journal of Biological Chemistry 248:5409–5413
    [Google Scholar]
  21. Wiame J. M. 1971; The regulation of arginine metabolism in Saccharomyces cerevisiae: exclusion mechanism. In Current Topics in Cellular Regulation 4 pp. 1–38 Horecker B. L., Stadtman E. R. Edited by New York: Academic Press.;
    [Google Scholar]
  22. Yemm E. W., Cocking E. C. 1955; The determination of amino acids with ninhydrin. Analyst 80:209–214
    [Google Scholar]
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