SUMMARY: Gonococci adapted to growth in chambers implanted subcutaneously into guinea pigs are resistant to killing by human serum. This resistance is lost after a few generations both in culture medium and in fluid taken from guinea-pig chambers. The rate of loss is too rapid to occur by mutation and selection. Furthermore, the resistance is regained after a few generations when bacteria from the first culture are inoculated back into guinea-pig chambers Hence the loss of serum resistance and the gain are probably due to phenotypically controlled events. Such events could be important in the pathogenicity of


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