1887

Abstract

Gonococci adapted to growth in chambers implanted subcutaneously into guinea pigs are resistant to killing by human serum. This resistance is lost after a few generations both in culture medium and in fluid taken from guinea-pig chambers. The rate of loss is too rapid to occur by mutation and selection. Furthermore, the resistance is regained after a few generations when bacteria from the first culture are inoculated back into guinea-pig chambers . Hence the loss of serum resistance and the gain are probably due to phenotypically controlled events. Such events could be important in the pathogenicity of .

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-103-1-69
1977-11-01
2021-05-07
Loading full text...

Full text loading...

/deliver/fulltext/micro/103/1/mic-103-1-69.html?itemId=/content/journal/micro/10.1099/00221287-103-1-69&mimeType=html&fmt=ahah

References

  1. Ellwood D. C., Tempest D. W. 1972; Effects of environment on bacterial wall content and composition. Advances in Microbial Physiology 7:83–117
    [Google Scholar]
  2. Finch J., Brown M. 1976; The effect of growth environment on the killing of chemostat grown Pseudomonas aeruginosa by phagocytes and cationic proteins. Proceedings of the Society for General Microbiology 3:82–83
    [Google Scholar]
  3. Glynn A. A., Ward M. E. 1970; Nature and heterogeneity of the antigens of Neisseria gonorrhoeae involved in the serum bactericidal reaction. Infection and Immunity 2:162–168
    [Google Scholar]
  4. Kellogg D. S., Peacock W. L., Deacon W. E., Brown L., Pirkle C. I. 1963; Neisseria gonorrhoeae. I. Virulence genetically linked to clonal variation. Journal of Bacteriology 85:1274–1279
    [Google Scholar]
  5. Kellogg D. S., Cohen I. R., Norins L. C., Schroeter A. L., Reising G. 1968; Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 months in vitro. Journal of Bacteriology 96:596–605
    [Google Scholar]
  6. Killington R. A., Williams A. E., Ratcliffe N. A., Whitehead T. P., Smith H. 1971; Hypoglycaemia and malignancy differences of closely related sublines of a rat tumour. British Journal of Cancer 25:93–105
    [Google Scholar]
  7. McCutchan J. A., Levine S., Braude A. I. 1976; Influence of colony type on susceptibility of gonococci to killing by human serum. Journal of Immunology 116:1652–1655
    [Google Scholar]
  8. Penn C. W., Sen D., Veale D. R., Parsons N. J., Smith H., Witt K. 1976; Morphological, biological and antigenic properties of Neisseria gonorrhoeae adapted to growth in guinea-pig subcutaneous chambers. Journal of General Microbiology 97:35–43
    [Google Scholar]
  9. Penn C. W., Parsons N. J., Sen D., Veale D. R., Smith H. 1977a; Immunization of guinea pigs with Neisseria gonorrhoeae: strain specificity and mechanisms of immunity. Journal of General Microbiology 100:159–166
    [Google Scholar]
  10. Penn C. W., Veale D. R., Smith H. 1977b; Selection from gonococci grown in vitro of a colony type with some virulence properties of organisms adapted in vivo. Journal of General Microbiology 100:147–158
    [Google Scholar]
  11. Schoolnik G. K., Buchanan T. M., Holmes K. K. 1976; Gonococci causing disseminated gonococcal infection are resistant to the bactericidal action of normal human serum. Journal of Clinical Investigation 58:1163–1173
    [Google Scholar]
  12. Veale D. R., Smith H., Witt K. A., Marshall R. B. 1975; Differential ability of colonial types of Neisseria gonorrhoeae to produce infection and an inflammatory response in subcutaneous perforated plastic chambers in guinea pigs and rabbits. Journal of Medical Microbiology 8:325–335
    [Google Scholar]
  13. Veale D. R., Sen D., Penn C. W., Finch H., Smith H. 1977; Interaction of Neisseria gonorrhoeae with guinea pig defence mechanisms in subcutaneously implanted chambers. FEMS Microbiology Letters 1:3–6
    [Google Scholar]
  14. Ward M. E., Watt P. J., Glynn A. A. 1970; Gonococci in urethral exudates possess a virulence factor lost on subculture. Nature London: 227:382–384
    [Google Scholar]
  15. Watt P. J., Glynn A. A., Ward M. E. 1972; Maintenance of virulent gonococci in laboratory culture. Nature New Biology 236:186
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-103-1-69
Loading
/content/journal/micro/10.1099/00221287-103-1-69
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error