The Effect of N6,O2′-Dibutyryl Adenosine-3′,5′-cyclic Monophosphate on Morphogenesis in Mucorales

SUMMARY: The effect of adding dibutyryl cyclic AMP to five species of Mucorales was tested. With Mucor hiemalis and M. mucedo a rapid halt of apical extension and a slower rate of resumed growth were observed together with marked morphological changes, including hyphal dilation, apical swelling, septation and multiple branching. Sporangiospore development, and the mating reaction in M. mucedo were both inhibited; carotene pigmentation was increased. Phycomyces blakesleeanus, Blakeslea trispora and Zygorhynchus moelleri were insensitive to dibutyryl cyclic AMP.