SUMMARY: Proline utilization during growth of is inhibited by the presence of other amino acids. Steady-state simultaneous utilization of proline and glutamate is possible, however, in a nitrogen-limited continuous culture. A switch to steady-state inhibition of proline utilization may be effected by a change in growth rate. Under the conditions studied, inhibition occurred on the catabolic route from proline to glutamate and was not mediated through the concentration of pool amino acids. In batch culture, the control site was shifted to proline permease by increasing the extracellular concentration of glutamate.


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