RT Journal Article SR Electronic(1) A1 Goldstein, Beth P. A1 Nielsen, Erik A1 Berti, Marisa A1 Bolzoni, Giuliana A1 Silvestri, Luigi G.YR 1977 T1 The Mechanism of Action of Nitro-heterocyclic Antimicrobial Drugs. Primary Target of 1-Methyl-2-nitro-5-vinylimidazole is DNA JF Microbiology, VO 100 IS 2 SP 271 OP 281 DO https://doi.org/10.1099/00221287-100-2-271 PB Microbiology Society, SN 1465-2080, AB Summary The antimicrobial drug 1-methyl-2-nitro-5-vinylimidazole (MEV) preferentially blocked DNA synthesis, was mutagenic and induced coliphage λ in Escherichia coli. The antibacterial effects of MEV are the consequences of repairable damage to DNA, as shown by hypersensitivity of recA and uvr strains to MEV and related drugs, stimulation by MEV of DNA turnover which was dependent on the product of the uvrA gene, and the presence of cross-links in DNA from MEV-treated bacteria., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-100-2-271