1887

Abstract

SUMMARY: Colloidal copper sulphide is inhibitory to staphylococci and a number of other Gram-positive organisms, but has little effect on Gram-negative organisms. Its formation when cystine and peptides containing cystine are autoclaved with copper is thought to be responsible for the anti-staphylococcal activity of heat-sterilized copper-containing peptone solutions. Colloidal sulphur is active against the cocci but the inhibition differs in some respects from that of copper sulphide, notably in the ease with which it can be reversed by cystine, cysteine and mercapto-acetic (thioglycollic) acid. Iron and manganese sulphides also inhibit bacterial growth and the possible significance of this inhibition on the production of anaerobic toxins is discussed.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-10-3-509
1954-06-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/micro/10/3/mic-10-3-509.html?itemId=/content/journal/micro/10.1099/00221287-10-3-509&mimeType=html&fmt=ahah

References

  1. Ephraim F. 1943 Inorganic Chemistry London: Gurney and Jackson;
    [Google Scholar]
  2. Fildes P., Richardson G. M. 1937; The nutrition of Staphylococcus aureus: sulphur requirements. Brit. J. exp. Path 18:292
    [Google Scholar]
  3. Knight B. C. J. G. 1941; Factors in the cultivation of anaerobic bacteria. Chem. & Ind. (Rev.) 60:369
    [Google Scholar]
  4. Lawson G. B. 1934; The inhibitory action of sulphur on the growth of tubercle bacilli. Amer. Rev. Tuberc 29:651
    [Google Scholar]
  5. Lepper E., Martin C. J. 1929; The chemical mechanisms exploited in the use of meat media for the cultivation of anaerobes. Brit. J. exp. Path 10:327
    [Google Scholar]
  6. Libenson L., Hadley F. P., McIlroy A. P., Wentzel V. M., Mellon R. 1953; Antibacterial effect of elemental sulfur. J. infect. Dis 93:28
    [Google Scholar]
  7. Massey A. B., Snyder G. E. 1936; Inhibitory action of colloidal sulphur in Corpers agar on the growth of 4 strains of Mycobacterium tÜberculosis var. hominis. Amer. J. publ. Hlth 26:811
    [Google Scholar]
  8. O’Meara R. A. Q., Macsween J. C. 1936; The failure of staphylococcus to grow from small inocula in routine laboratory media. J. Path. Bact 43:373
    [Google Scholar]
  9. O’Meara R. A. Q., Macsween J. C. 1937; The influence of copper in peptones on the growth of certain pathogens in peptone broth. J. Path. Bact 44:225
    [Google Scholar]
  10. Proom H., Woiwod A. J. 1949; The examination by partition paper chromatography of the nitrogen metabolism of bacteria. J. gen. Microbiol 3:319
    [Google Scholar]
  11. Schuhardt V. T., Rode L. J., Foster J. W., Oglesby G. 1949; An antibrucella factor in peptones. J. Bact 57:1
    [Google Scholar]
  12. Schuhardt V. T., Rode L. J., Oglesby G. 1949; Toxicity of certain amino acids for brucellae. J. Bact 58:665
    [Google Scholar]
  13. Schuhardt V. T., Rode L. J., Oglesby G., Lankford C. E. 1950; The development of peptone toxicity for brucellae with ageing and the correlation of this toxicity with the probable oxidation of cystine. J. Bact 60:655
    [Google Scholar]
  14. Schuhardt V. T., Rode L. J., Oglesby G., Lankford C. E. 1952; The toxicity of elemental sulphur for brucellae. J. Bact 63:123
    [Google Scholar]
  15. Sterne M., Wentzel L. M. 1950; A new method for the large-scale production of high-titre botulinum formol-toxoid Types C and D. J. Immunol 65:175
    [Google Scholar]
  16. Weld J. T., Gunther A. 1947; The antibacterial properties of sulphur. J. exp. Med 85:531
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-10-3-509
Loading
/content/journal/micro/10.1099/00221287-10-3-509
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error