1887

Abstract

Staphylococci produce coagulase in two forms. One is bound to the cell wall and is responsible for the slide test. The other is liberated as free coagulase in the medium and is responsible for the tube test. Bound coagulase acts directly on the fibrinogen of certain animals which then causes clumping of the staphylococcal cells, while free coagulase acts on the prothrombin of certain animals to give a thrombin-like product. Bound coagulase is antigenically distinct from free coagulase. It is released during autolysis and it can be used to produce specific antibodies in rabbits.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-10-3-427
1954-06-01
2022-01-22
Loading full text...

Full text loading...

/deliver/fulltext/micro/10/3/mic-10-3-427.html?itemId=/content/journal/micro/10.1099/00221287-10-3-427&mimeType=html&fmt=ahah

References

  1. Bekker J. H. 1947; Studies on staphylocoagulase. II. Antistaphylocoagulase in human serum. Leeuwenhoek ned. Tijdschr 13:128
    [Google Scholar]
  2. Berger F. M. 1943; Clumping of pathogenic staphylococci in plasma. J. Path. Bact 55:435
    [Google Scholar]
  3. Birch-Hirschfeld L. 1934; Über die Agglutination von Staphylokokken durch Bestandteile des Säugetierblutplasmas. Klin. Wschr 13:331
    [Google Scholar]
  4. Cadness-Graves B., Williams R., Harper G. J., Miles A. A. 1943; Slide test for coagulase positive staphylococci. Lancet i:736
    [Google Scholar]
  5. Duthie E. S. 1952; Variation in the antigenic composition of staphylococcal coagulase. J. gen. Microbiol 7:320
    [Google Scholar]
  6. Duthie E. S. 1954; The production of free staphylococcal coagulase. J. gen. Microbiol 10:437
    [Google Scholar]
  7. Duthie E. S., Lorenz L. 1949; Protease inhibitors. I. Assay and nature of serum antiprotease. Biochem. J 44:167
    [Google Scholar]
  8. Duthie E. S., Lorenz L. 1952; Staphylococcal coagulase: mode of action and antigenicity. J. gen. Microbiol 6:95
    [Google Scholar]
  9. Field H. I., Smith H. W. 1945; Coagulase test for staphylococci. J. comp. Path 55:63
    [Google Scholar]
  10. Hale J. H., Smith W. 1945; The influence of coagulase on the phagocytosis of staphylococci. Brit. J. exp. Path 26:209
    [Google Scholar]
  11. Jaques L. B. 1943; The reducing properties of fibrinogen. Biochem. J 37:344
    [Google Scholar]
  12. Linsell W. D., Gorill R. H. 1951; The effect of heat and sodium ethyl mercurithio-salicylate on the staphylocoagulase test. J. clin. Path 4:73
    [Google Scholar]
  13. Loeb L. 1903; The influence of certain bacteria on the coagulation of the blood. J. med. Res 10:407
    [Google Scholar]
  14. Lominski I., Roberts G. B. 1946; A substance in human serum inhibiting staphylocoagulase. J. Path. Bact 58:187
    [Google Scholar]
  15. Miale J. B. 1949; The role of staphylocoagulase in blood coagulation. I. The reaction of staphylocoagulase with coagulase-globulin (CG) to form coagulase-thrombin (CT). Blood 4:1039
    [Google Scholar]
  16. Much H. 1908; Über eine Vorstufe des Fibrinfermentes in Kulturen von Staphylokokkus aureus. Biochem. Z 14:143
    [Google Scholar]
  17. Rammelkamp C. H., Badger G. F., Dingle J. H., Feller A. E., Hodges R. G. 1949; A quantitative method for measuring staphylococcal anticoagulase. Proc. Soc. exp. Biol., N.Y 72:210
    [Google Scholar]
  18. Rammelkamp C. H., Hezebicks M. M., Dingle J. H. 1950; Specific coagulase of Staphylococcus aureus. J. exp. Med 91:295
    [Google Scholar]
  19. Rogers D. E., Tompsett R. 1952; The survival of staphylococci within human leukocytes. J. exp. Med 95:
    [Google Scholar]
  20. Smith W., Hlale J. H. 1944; The nature and mode of action of staphylococcus coagulase. Brit. J. exp. Path 25:101
    [Google Scholar]
  21. Smith W., Hale J. H., Smith M. M. 1947; The role of coagulase in staphylococcal infections. Brit. J. exp. Path 28:57
    [Google Scholar]
  22. Tager M., Hales H. 1948a; Studies on the coagulase-reacting factor. II. Properties of coagulase reacting factor and relation to blood-clotting components. J. Immunol 60:1
    [Google Scholar]
  23. Tager M., Hales H. 1948b; Differences in the resistance of human plasmas to staphylocoagulase. Yale J. Biol. Med 21:91
    [Google Scholar]
  24. Tillett W. S., Abernethy T. J. 1932; Serological reactions with haemolytic streptococci in acute bacterial infections. Johns Hopk. Hosp. Bull 50:270
    [Google Scholar]
  25. Tillett W. S., Garner R. L. 1934; The agglutination of haemolytic streptococci by plasma and fibrinogen. A comparison of the phenomenon to serological reactions with the same organism. Johns Hopk. Hosp. Bull 54:145
    [Google Scholar]
  26. Weaver G. H. 1904; Agglutination of streptococci, especially those cultivated from cases of scarlatina by human sera. J. infect. Dis 1:91
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-10-3-427
Loading
/content/journal/micro/10.1099/00221287-10-3-427
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error