%0 Journal Article
%A Nossal, G. J. V.
%A De Burgh, P. M.
%T Ectromelia Virus Multiplication in Mouse Liver
%D 1954
%J Microbiology,
%V 10
%N 3
%P 345-352
%@ 1350-0872
%R https://doi.org/10.1099/00221287-10-3-345
%I Microbiology Society,
%X SUMMARY: The multiplication of ectromelia virus in mouse liver cells has been studied using intravenous inocula of 106 to 1010 LD50 doses. About 30% of this virus is found in the liver in 5 min., and most of this disappears as infective virus in the next hour. After a lag period, the length of which depends on the number of LD50 doses/cell which initiated the infection, the virus titre increases again to the 5 min. level. Subsequently, steps of multiplication, each separated by a lag period, occur within each cell. The efficiency of virus multiplication over the range tested is independent of the infecting dose.
%U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-10-3-345