@article{mbs:/content/journal/micro/10.1099/00221287-10-3-345, author = "Nossal, G. J. V. and De Burgh, P. M.", title = "Ectromelia Virus Multiplication in Mouse Liver", journal= "Microbiology", year = "1954", volume = "10", number = "3", pages = "345-352", doi = "https://doi.org/10.1099/00221287-10-3-345", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-10-3-345", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "SUMMARY: The multiplication of ectromelia virus in mouse liver cells has been studied using intravenous inocula of 106 to 1010 LD50 doses. About 30% of this virus is found in the liver in 5 min., and most of this disappears as infective virus in the next hour. After a lag period, the length of which depends on the number of LD50 doses/cell which initiated the infection, the virus titre increases again to the 5 min. level. Subsequently, steps of multiplication, each separated by a lag period, occur within each cell. The efficiency of virus multiplication over the range tested is independent of the infecting dose.", }