1887

Abstract

SUMMARY: The multiplication of ectromelia virus in mouse liver cells has been studied using intravenous inocula of 10 to 10 LD50 doses. About 30% of this virus is found in the liver in 5 min., and most of this disappears as infective virus in the next hour. After a lag period, the length of which depends on the number of LD50 doses/cell which initiated the infection, the virus titre increases again to the 5 min. level. Subsequently, steps of multiplication, each separated by a lag period, occur within each cell. The efficiency of virus multiplication over the range tested is independent of the infecting dose.

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/content/journal/micro/10.1099/00221287-10-3-345
1954-06-01
2022-01-23
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