Observations on the Mode of Action of Antibiotic Synergism and Antaǵonism Free

Abstract

SUMMARY: Inactive analogues and degradation products of active antibiotics failed to participate in either synergistic or antagonistic antimicrobial action in combination with active antibiotics. Streptobiosamine hydrochloride contaminated with 2–3% (w/w) streptomycin was synergistic with other antibiotics because of the active streptomycin present. The ratio of the smallest amount of antibiotic participating in synergism to that having independent antimicrobial activity varied with the drug and the micro-organism. Synergism with another antibiotic usually required from 1/20 to 1/3 of the minimal inhibitory concentration of an antibiotic when acting alone. Streptomycin, however, in 1/1000 of the minimal inhibitory concentration was synergistic with penicillin in its action on a strain of .

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-10-2-191
1954-04-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/micro/10/2/mic-10-2-191.html?itemId=/content/journal/micro/10.1099/00221287-10-2-191&mimeType=html&fmt=ahah

References

  1. Chabbert Y. 1953; Action des associations d’antibiotiques sur les germes aerobies. Ann. Inst. Pasteur 84:545
    [Google Scholar]
  2. Eagle H. 1951; Further observations on the zone phenomenon in the bactericidal action of penicillin. J. Bact 62:663
    [Google Scholar]
  3. Gunnison J. B., Coleman V. R., Jawetz E. 1950; Interference of aureomycin and of terramycin with action of penicillin in vitro. Proc. Soc. exp. Biol., N.Y 75:549
    [Google Scholar]
  4. Gunnison J. B., Jawetz E., Coleman V. R. 1950; The effect of combinations of antibiotics on enterococci in vitro. J. Lab. clin. Med 36:900
    [Google Scholar]
  5. Jawetz E., Gunnison J. B. 1953; Antibiotic synergism and antagonism: An assessment of the problem. Pharm. Rev 5: 175
    [Google Scholar]
  6. Jawetz E., Gunnison J. B., Coleman V. R. 1950; The combined action of penicillin with streptomycin or Chloromycetin on enterococci in vitro. Science 111:254
    [Google Scholar]
  7. Jawetz E., Gunnison J. B., Speck R. S., Coleman V. R. 1951; Studies on antibiotic synergism and antagonism. The interference of chloramphenicol with the action of penicillin. Arch, intern. Med 87:349
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-10-2-191
Loading
/content/journal/micro/10.1099/00221287-10-2-191
Loading

Data & Media loading...

Most cited Most Cited RSS feed