1887

Abstract

SUMMARY: From the existing methods for identifying common antibiotics it is possible to select tests for recognizing one or more of fourteen known antibiotics in crude culture medium. These tests, given in tabular form, are: (1) stability at pH 2·0 and 9·5; (2) ether-water partition at pH 2·0, 6·0–7·0 and 9·0; and (3) relative activity towards specified strains of and . Further tests depend on destruction of penicillin by penicillinase, colour reactions, and volatility of aspergillic acid in steam. For final confirmation, isolation of the antibiotic may be necessary.

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1947-06-01
2024-12-13
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References

  1. Abraham E. P., Chain E. 1942; Purification and some physical and chemical properties of penicillin. Brit. J. exp. Path 23:103
    [Google Scholar]
  2. Anslow W. K., Raistrick H. 1938a; Fumigatin (3-hydroxy-4-methoxy-2:5-toluquinone) and spinulosin (3:6 dihydroxy-4-methoxy-2:5-toluquinone), metabolic products respectively of Aspergillus fumigatus Fresenius and Penicillium spinulosum Thom. Biochem. J 32:687
    [Google Scholar]
  3. Anslow W. K., Raistrick H. 1938b; Spinulosin (3:6-dihydroxy-4-methoxy-2-5- toluquinone) a metabolic product of a strain of Aspergillus fumigatus Fresenius. Biochem. J 32:2288
    [Google Scholar]
  4. Birkinshaw J. H., Raistrick H. 1931; On a new methoxy-dihydroxy-toluquinone produced from glucose by a species of Penicillium of the P. spinulosinseries. Philos. Trans 220:245
    [Google Scholar]
  5. Birkinshaw J. H., Charles J. H. V., Lilly C. H., Raistrick H. 1931; Kojic acid (5-hydroxy-2-hydroxymethyl-γ-pyrone). Philos. Trans. B 220: 127
    [Google Scholar]
  6. Birkinshaw J. H., Oxford A. E., Raistrick H. 1936; Penicillic acid, a metabolic product of Penicillium puberulum Bainier, and P. cyclopium Westling. Biochem. J 30:394
    [Google Scholar]
  7. Chain E., Florey H. W., Jennings M. A. 1942; An antibacterial substance produced by Penicillium claviforme. Brit. J. exp. Path 23:202
    [Google Scholar]
  8. Chain E., Florey H. W., Jennings M. A., Williams T. I. 1943; Helvolic acid, an antibiotic produced by Aspergillus fumigatus, Mut. HelvolaYuill. Brit. J. exp. Path 24:108
    [Google Scholar]
  9. Clutterbuck P. W., Raistrick H. 1933; The molecular constitution of the metabolic products of Penicillium brevi-compactum Dierckx and related species. Biochem. J 27:654
    [Google Scholar]
  10. Duthie E. S. 1944; The production of penicillinase by organisms of the subtilis group. Brit. J. exp. Path 25:96
    [Google Scholar]
  11. Eisman P. C., Marsh W. S., Mayer R. L. 1946; Differentiation of antibiotics by resistant strains. Science 103:673
    [Google Scholar]
  12. Florey H. W., Gilliver K., Jennings M. A., Sanders A. G. 1946; Mycophenolic acid, an antibiotic from Penicillium brevi-compactum Dierckx. Lancet250 p. 46
    [Google Scholar]
  13. Furtado A. Da R. 1944; Pesquisa de atividade antibacteriana com 180 amostras de Aspergillus Micheli, 1729. Mem. Inst. Osw. Cruz 61:2–205
    [Google Scholar]
  14. Gardner A. D., Chain E. 1942; Proactinomycin: a ‘bacteriostatic’ produced by a species of Proactinomyces. Brit. J. exp. Path 23:123
    [Google Scholar]
  15. Heatherington A. C., Raistrick H. 1931; On the production and chemical constitution of a new yellow colouring matter, citrinin, produced from glucose by Penicillium citrinum Thom. Philos. Trans. B 220:269
    [Google Scholar]
  16. Heatley N. G. 1944; A method for the assay of penicillin. Biochem. J 38:61
    [Google Scholar]
  17. Jennings M. A., Williams T. I. 1945; Production of kojic acid by Aspergillus effusus Tiraboschi. Nature; Lond: 155302
    [Google Scholar]
  18. Johnson J. R., Bruce W. F., Dutcher J. D. 1943; Gliotoxin, the antibiotic principle of Gliocladium fimbriatum. I. Production, physical and biological properties. J. Amer. chem. Soc 65:2005
    [Google Scholar]
  19. Menzel A. E. O., Wintersteiner O., Rake G. 1943; Note on antibiotic substances elaborated by an Aspergillus flavus strain and by an unclassified mould. J. Bact 46:109
    [Google Scholar]
  20. Oxford A. E., Raistrick H. 1942; Antibacterial substances from moulds. Part IV. Spinulosin and fumigatin, metabolic products of Penicillium spinulosin Thom and Aspergillus fumigatus Fresenius. Chem. Ind 20:128
    [Google Scholar]
  21. Oxford A. E., Raistrick H., Smith G. 1942a; Antibacterial substances from moulds. Part II. Penicillic acid, a metabolic product of Penicillium puberulum Bainier and Penicillium cyclopium Westling. Chem. Ind 20:22
    [Google Scholar]
  22. Oxford A. E., Raistrick H., Smith G. 1942b; Antibacterial substances from moulds. Part VI. Puberulic acid, C8H6O8, and Puberulonic acid, C8H4O6, metabolic products of a number of species of Penicillium. Chem. Ind 20:485
    [Google Scholar]
  23. Robbins W. J., Hervey A., Davidson R. W., Ma R., Robbins W. C. 1945; A survey of some wood destroying and other fungi for antibacterial activity. Bull. Torrey bot. Cl 72:165
    [Google Scholar]
  24. Schatz A., Bugie E., Waksman S. A. 1944; Streptomycin, a substance exhibiting antibiotic activity against Gram-positive and Gram-negative bacteria. Proc. Soc. exp. Biol., N.Y 55:66
    [Google Scholar]
  25. Schenck J. R., Spielman M. A. 1945; The formation of maltol by the degradation of streptomycin. J. Amer. chem. Soc 67:2276
    [Google Scholar]
  26. Stansly P. G. 1946; The presumptive identification of antibiotics. Science 103:402
    [Google Scholar]
  27. Tauber H., Laufer S., Goll M. 1942; A colour test for citrinin and a method for its preparation. J. Amer. chem. Soc 64:2228
    [Google Scholar]
  28. Weindling R. 1941; Experimental configuration of the mould toxin of Gliocladium and Trichoderma. Phytopathology 31:991
    [Google Scholar]
  29. White E. C., Hill J. H. 1943; Studies on antibacterial products formed by moulds. I. Aspergillic acid, a product of a strain of Aspergillus flavus . J. Bact 45:433
    [Google Scholar]
  30. Wiedling S. 1944; The production of antibiotics by Penicillium species. Bot. Notiser p. 433
    [Google Scholar]
  31. Wilkins W. H. 1946; Investigation into the production of bacteriostatic substances by fungi. Preliminary examination of the fifth 100 species, all Basidiomycetes, mostly of the wood-destroying type. Brit. J. exp. Path 27:140
    [Google Scholar]
  32. Wilkins W. H., Harris G. C. M. 1942; Investigation into the production of bacteriostatic substances by fungi. I. Preliminary examination of 100 fungal species. Brit. J. exp. Path 23:166
    [Google Scholar]
  33. Wilkins W. H., Harris G. C. M. 1943; Investigation into the production of bacteriostatic substances by fungi. Preliminary examination of the second 100 fungal species. Brit. J. exp. Path 24:141
    [Google Scholar]
  34. Wilkins W. H., Harris G. C. M. 1944a; Investigation into the production of bacteriostatic substances by fungi. Preliminary examination of the third 100 fungi, with special reference to strain variation among species of Aspergilli. Trans. Brit, mycol. Soc 27:113
    [Google Scholar]
  35. Wilkins W. H., Harris G. C. M. 1944b; Investigation into the production of bacteriostatic substances by fungi. Preliminary examination of a fourth 100 fungal species, all Penicillia. Brit. J. exp. Path 25:135
    [Google Scholar]
  36. Wilkins W. H., Harris G. C. M. 1944c; Investigation into the production of bacteriostatic substances by fungi. Examination of the larger Basidiomycetes. Ann. appl. Biol 31:261
    [Google Scholar]
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